5545-17-5
- Name: N,N'-Diacetyl-L-cystine
- Chemical Name: (ac-cys-oh)2
- CAS Number: 5545-17-5
- Molecular Formula: C10H16N2O6S2
- Molecular Weight: 324.374
- Catalog: Biochemical Amino acids and their derivatives Other amino acid derivatives
- Create Date: 2018-06-20 05:53:28
- Modify Date: 2025-08-20 17:08:39
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N,N'-diacetyl-L-cystine (DiNAC) is the disulphide dimer of N-acetylcysteine with immunomodulating properties. N,N'-diacetyl-L-cystine is a potent, orally active modulator of contact sensitivity/delayed type hypersensitivity reactions in rodents. N,N'-diacetyl-L-cystine also has antiatherosclerotic effects in Watanabe-heritable hyperlipidemic rabbit (WHHL) rabbits[1][2].
| Name | (ac-cys-oh)2 |
|---|---|
| Synonyms |
N,N`-Diacetyl-L-cystine
N,N'-Diacetyl-L-cystine N,N'-diacetyl-cystine N-acetyl-L-cystine ACETYL-L-CYSTINE DiNAC L-Cystine, N,N'-diacetyl- Cystine, N,N'-diacetyl-, L- diacetylcysteine L-Cystine,N,N'-diacetyl N,N''-Diacetyl-L-cysteine N-ACETYL CYSTINE |
| Description | N,N'-diacetyl-L-cystine (DiNAC) is the disulphide dimer of N-acetylcysteine with immunomodulating properties. N,N'-diacetyl-L-cystine is a potent, orally active modulator of contact sensitivity/delayed type hypersensitivity reactions in rodents. N,N'-diacetyl-L-cystine also has antiatherosclerotic effects in Watanabe-heritable hyperlipidemic rabbit (WHHL) rabbits[1][2]. |
|---|---|
| Related Catalog | |
| Target |
Immunomodulator[1] |
| In Vivo | N,N'-Diacetyl-L-cystine (DiNAC; 0-973.11 μg/kg; oral administration; daily; for 12 weeks; WHHL rabbits) treatment reduces by 50% thoracic aorta atherosclerosis, without affecting plasma lipid levels[1]. Animal Model: Male heritable hyperlipidemic rabbit (WHHL) rabbits (10-22 weeks)[1] Dosage: 0 μg/kg, 9.73 μg/kg, or 973.11 μg/kg Administration: Oral administration; daily; for 12 weeks Result: Reduced by 50% thoracic aorta atherosclerosis, without affecting plasma lipid levels. |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 715.5±60.0 °C at 760 mmHg |
| Melting Point | 55-72ºC |
| Molecular Formula | C10H16N2O6S2 |
| Molecular Weight | 324.374 |
| Flash Point | 386.5±32.9 °C |
| Exact Mass | 324.044983 |
| PSA | 183.40000 |
| LogP | 0.46 |
| Vapour Pressure | 0.0±5.0 mmHg at 25°C |
| Index of Refraction | 1.583 |
| Storage condition | -15°C |
| Stability | Moisture Sensitive |
| HS Code | 29225090 |
|---|
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| Literature: Oba, Makoto; Tanaka, Kazuhito; Nishiyama, Kozaburo; Ando, Wataru Journal of Organic Chemistry, 2011 , vol. 76, # 10 p. 4173 - 4177 |
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| Literature: Stamler, Jonathan S.; Loscalzo, Joseph Analytical Chemistry, 1992 , vol. 64, # 7 p. 779 - 785 |
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| Literature: Journal of Biological Chemistry, , vol. 94, p. 244 Archives of Biochemistry, , vol. 18, p. 379 |
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| Literature: Watzig; Dette; Aigner; Wilschowitz Pharmazie, 1994 , vol. 49, # 4 p. 249 - 252 |
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| Literature: Inorganic chemistry, , vol. 39, # 8 p. 1728 - 1734 |
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| Literature: Biochemical Journal, , vol. 25, p. 619 Rikagaku Kenkyusho Iho, , vol. 8, p. 647,650 Chem. Zentralbl., , vol. 100, # II p. 2770 |
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| Literature: Biochemical Journal, , vol. 25, p. 619 Rikagaku Kenkyusho Iho, , vol. 8, p. 647,650 Chem. Zentralbl., , vol. 100, # II p. 2770 |
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| Literature: Photochemistry and Photobiology, , vol. 71, # 3 p. 273 - 280 |
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| Literature: Canadian Journal of Chemistry, , vol. 76, # 6 p. 789 - 794 |
| Precursor 8 | |
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| DownStream 3 | |
