Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: L-Cystine,N,N'-diacetyl-
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Purity: 98.0%
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5545-17-5

5545-17-5 structure

Name: N,N'-Diacetyl-L-cystine
Chemical Name: (ac-cys-oh)2
CAS Number: 5545-17-5
Molecular Formula: C₁₀H₁₆N₂O₆S₂
Molecular Weight: 324.374
Catalog: Biochemical Amino acids and their derivatives Other amino acid derivatives
Create Date: 2018-06-20 05:53:28
Modify Date: 2026-07-02 11:03:57
N,N'-diacetyl-L-cystine (DiNAC) is the disulphide dimer of N-acetylcysteine with immunomodulating properties. N,N'-diacetyl-L-cystine is a potent, orally active modulator of contact sensitivity/delayed type hypersensitivity reactions in rodents. N,N'-diacetyl-L-cystine also has antiatherosclerotic effects in Watanabe-heritable hyperlipidemic rabbit (WHHL) rabbits[1][2].

Name	(ac-cys-oh)2
Synonyms	Acetylcysteine Disulfide Dimer N-acetyl-L-cystine DiNAC Acetylcysteine impurity C (A0152000)Q: What is Acetylcysteine impurity C (A0152000) Q: What is the CAS Number of Acetylcysteine impurity C (A0152000) Acetylcysteine Impurity 38 N,N-diacetylcystine L-Cystine,N,N'-diacetyl (AC-CYS-OH)2 //BP N-ACETYL CYSTINE (Ac-L-Cys-OH)2 N-ALPHA-ACETYL-L-CYSTINE N,N'-diacetyl-cystine ACETYL-L-CYSTINE (2R)-3-{[(2R)-2-cboxy-2-acetamidoethyl]disulfanyl}-2-acetamidopropanoic acid Acetylcysteine IMpurity C (AC-CYS-OH)2 N,N'-Diacetyl-L-Cystine L-Cystine, N,N'-diacetyl Acetylcysteine Impurity 5（Acetylcysteine Impurity C） N,N''-Diacetyl-L-cysteine Acetylcysteine impurity C CRS Acetyl Cysteine BP Impurity C diacetylcysteine (2R,2'R)-3,3'-disulfanediylbis(2-acetamidopropanoic acid) 3,3'-Dithiobis[(R)-2-acetylaminopropionic acid] (Ac-L-Cys-OH)2(Disulfide bond) , Chiral purity) N,N`-Diacetyl-L-cystine N,N’-Diacetyl-L-cystine (Ac-Cys-OH)2 (Disulfide bond) S-(((R)-2-acetamido-2-cboxyethyl)thio)-N-acetylcysteine N,N''-Diacetyl-L-cystine, 10 mM in DMSO ACETYLCYSTEINE IMPURITY C / N,N`-DIACETYL- L-CYSTINE

Description	N,N'-diacetyl-L-cystine (DiNAC) is the disulphide dimer of N-acetylcysteine with immunomodulating properties. N,N'-diacetyl-L-cystine is a potent, orally active modulator of contact sensitivity/delayed type hypersensitivity reactions in rodents. N,N'-diacetyl-L-cystine also has antiatherosclerotic effects in Watanabe-heritable hyperlipidemic rabbit (WHHL) rabbits[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others
Target	Immunomodulator[1]
In Vivo	N,N'-Diacetyl-L-cystine (DiNAC; 0-973.11 μg/kg; oral administration; daily; for 12 weeks; WHHL rabbits) treatment reduces by 50% thoracic aorta atherosclerosis, without affecting plasma lipid levels[1]. Animal Model: Male heritable hyperlipidemic rabbit (WHHL) rabbits (10-22 weeks)[1] Dosage: 0 μg/kg, 9.73 μg/kg, or 973.11 μg/kg Administration: Oral administration; daily; for 12 weeks Result: Reduced by 50% thoracic aorta atherosclerosis, without affecting plasma lipid levels.
References	[1]. Wågberg M, et al. N,N'-diacetyl-L-cystine (DiNAC), the disulphide dimer of N-acetylcysteine, inhibits atherosclerosis in WHHL rabbits: evidence for immunomodulatory agents as a new approach to prevent atherosclerosis. J Pharmacol Exp Ther. 2001 Oct;299(1):76-82. [2]. Särnstrand B, et al. N,N'-Diacetyl-L-cystine-the disulfide dimer of N-acetylcysteine-is a potent modulator of contact sensitivity/delayed type hypersensitivity reactions in rodents. J Pharmacol Exp Ther. 1999 Mar;288(3):1174-84.

Density	1.5±0.1 g/cm3
Boiling Point	715.5±60.0 °C at 760 mmHg
Melting Point	55-72ºC
Molecular Formula	C₁₀H₁₆N₂O₆S₂
Molecular Weight	324.374
Flash Point	386.5±32.9 °C
Exact Mass	324.044983
PSA	183.40000
LogP	0.46
Vapour Pressure	0.0±5.0 mmHg at 25°C
Index of Refraction	1.583
Storage condition	-15°C
Stability	Moisture Sensitive

HS Code	29225090

616-91-1

~98%

5545-17-5

Literature: Oba, Makoto; Tanaka, Kazuhito; Nishiyama, Kozaburo; Ando, Wataru Journal of Organic Chemistry, 2011 , vol. 76, # 10 p. 4173 - 4177

616-91-1

~0%

5545-17-5

56577-02-7

Literature: Stamler, Jonathan S.; Loscalzo, Joseph Analytical Chemistry, 1992 , vol. 64, # 7 p. 779 - 785

56-89-3

108-24-7

5545-17-5

Literature: Journal of Biological Chemistry, , vol. 94, p. 244 Archives of Biochemistry, , vol. 18, p. 379

52-90-4

108-24-7

~22%

5545-17-5

Literature: Watzig; Dette; Aigner; Wilschowitz Pharmazie, 1994 , vol. 49, # 4 p. 249 - 252

616-91-1

124721-03-5

5545-17-5

1034767-14-0

Literature: Inorganic chemistry, , vol. 39, # 8 p. 1728 - 1734

32381-28-5

5545-17-5

Literature: Biochemical Journal, , vol. 25, p. 619 Rikagaku Kenkyusho Iho, , vol. 8, p. 647,650 Chem. Zentralbl., , vol. 100, # II p. 2770

1033249-05-6

5545-17-5

Literature: Biochemical Journal, , vol. 25, p. 619 Rikagaku Kenkyusho Iho, , vol. 8, p. 647,650 Chem. Zentralbl., , vol. 100, # II p. 2770

56577-02-7

5545-17-5

Literature: Photochemistry and Photobiology, , vol. 71, # 3 p. 273 - 280

616-91-1

56577-02-7

5545-17-5

Literature: Canadian Journal of Chemistry, , vol. 76, # 6 p. 789 - 794

Precursor 8
616-91-1 56-89-3 108-24-7 52-90-4
124721-03-5 32381-28-5 1033249-05-6 56577-02-7
DownStream 3
56-89-3 32381-28-5 7664-41-7

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