Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: JUSTICIDIN B
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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17951-19-8

17951-19-8 structure

Name: JUSTICIDIN B
Chemical Name: 4-(1,3-benzodioxol-5-yl)-6,7-dimethoxy-1H-benzo[f][2]benzofuran-3-one
CAS Number: 17951-19-8
Molecular Formula: C₂₁H₁₆O₆
Molecular Weight: 364.34800
Catalog: Signaling Pathways Anti-infection Fungal
Create Date: 2018-03-06 08:00:00
Modify Date: 2024-01-02 19:58:12
Justicidin B is a potent anticancer lignan and proapoptotic agent. Justicidin B is also a bone resorption inhibitor, and has strong antiviral, fungicidal, antiprotozoal effects. Justicidin B significantly inhibits platelet aggregation[1][2][3].

Name	4-(1,3-benzodioxol-5-yl)-6,7-dimethoxy-1H-benzo[f][2]benzofuran-3-one
Synonyms	4,5-dimethoxy-3',4'-methylenedioxy-2,7'-cycloligna-7,7'-dieno-9,9'-lactone justicidin B

Description	Justicidin B is a potent anticancer lignan and proapoptotic agent. Justicidin B is also a bone resorption inhibitor, and has strong antiviral, fungicidal, antiprotozoal effects. Justicidin B significantly inhibits platelet aggregation[1][2][3].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Cardiovascular Disease Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal
In Vitro	Justicidin B 抑制致病真菌烟曲霉 (MIC ≥ 1 μg/mL)、黄曲霉 (MIC ≥ 12 μg/mL) 和白色念珠菌 (MIC ≥ 4 μg/mL) 的生长，但对新型隐球菌和头状芽孢杆菌无效[1]。 Justicidin B 还对罗得西亚布氏锥虫的锥体鞭毛体形式表现出很强的活性 (IC50 = 0.2 μg/mL)，对克氏锥虫 (IC50 = 2.6 μg/mL) 表现出中等活性[1]。 Justicidin B 在 MDA-MB-231 和 MCF-7 乳腺癌衍生细胞系中表现出细胞毒活性和诱导细胞凋亡。两种细胞系的 24 小时处理增加了凋亡 DNA 片段化的水平。MDA-MB-231 细胞与 Justicidin B 的接触导致 NFkB 表达的浓度依赖性降低；而 MCF-7 的处理与该转录因子表达的强烈增加一致[2]。
References	[1]. Jürg Gertsch, et al. Antifungal, antiprotozoal, cytotoxic and piscicidal properties of Justicidin B and a new arylnaphthalide lignan from Phyllanthus piscatorum. Planta Med. 2003 May;69(5):420-4. [2]. G Momekov, et al. Effect of justicidin B - a potent cytotoxic and pro-apoptotic arylnaphtalene lignan on human breast cancer-derived cell lines. Neoplasma. 2011;58(4):320-5. [3]. Iliana Ionkova, et al. Linum narbonense: A new valuable tool for biotechnological production of a potent anticancer lignan Justicidine B. Pharmacogn Mag. 2013 Jan;9(33):39-44.

Density	1.376g/cm3
Boiling Point	601.9ºC at 760 mmHg
Molecular Formula	C₂₁H₁₆O₆
Molecular Weight	364.34800
Flash Point	266ºC
Exact Mass	364.09500
PSA	63.22000
LogP	3.92310
Vapour Pressure	1.93E-14mmHg at 25°C
Index of Refraction	1.658

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