17951-19-8
17951-19-8 structure
- Name: JUSTICIDIN B
- Chemical Name: 4-(1,3-benzodioxol-5-yl)-6,7-dimethoxy-1H-benzo[f][2]benzofuran-3-one
- CAS Number: 17951-19-8
- Molecular Formula: C21H16O6
- Molecular Weight: 364.34800
- Catalog: Signaling Pathways Anti-infection Fungal
- Create Date: 2018-03-06 08:00:00
- Modify Date: 2024-01-02 19:58:12
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Justicidin B is a potent anticancer lignan and proapoptotic agent. Justicidin B is also a bone resorption inhibitor, and has strong antiviral, fungicidal, antiprotozoal effects. Justicidin B significantly inhibits platelet aggregation[1][2][3].
| Name | 4-(1,3-benzodioxol-5-yl)-6,7-dimethoxy-1H-benzo[f][2]benzofuran-3-one |
|---|---|
| Synonyms |
4,5-dimethoxy-3',4'-methylenedioxy-2,7'-cycloligna-7,7'-dieno-9,9'-lactone
justicidin B |
| Description | Justicidin B is a potent anticancer lignan and proapoptotic agent. Justicidin B is also a bone resorption inhibitor, and has strong antiviral, fungicidal, antiprotozoal effects. Justicidin B significantly inhibits platelet aggregation[1][2][3]. |
|---|---|
| Related Catalog | |
| In Vitro | Justicidin B 抑制致病真菌烟曲霉 (MIC ≥ 1 μg/mL)、黄曲霉 (MIC ≥ 12 μg/mL) 和白色念珠菌 (MIC ≥ 4 μg/mL) 的生长，但对新型隐球菌和头状芽孢杆菌无效[1]。 Justicidin B 还对罗得西亚布氏锥虫的锥体鞭毛体形式表现出很强的活性 (IC50 = 0.2 μg/mL)，对克氏锥虫 (IC50 = 2.6 μg/mL) 表现出中等活性[1]。 Justicidin B 在 MDA-MB-231 和 MCF-7 乳腺癌衍生细胞系中表现出细胞毒活性和诱导细胞凋亡。 两种细胞系的 24 小时处理增加了凋亡 DNA 片段化的水平。MDA-MB-231 细胞与 Justicidin B 的接触导致 NFkB 表达的浓度依赖性降低； 而 MCF-7 的处理与该转录因子表达的强烈增加一致[2]。 |
| References |
| Density | 1.376g/cm3 |
|---|---|
| Boiling Point | 601.9ºC at 760 mmHg |
| Molecular Formula | C21H16O6 |
| Molecular Weight | 364.34800 |
| Flash Point | 266ºC |
| Exact Mass | 364.09500 |
| PSA | 63.22000 |
| LogP | 3.92310 |
| Vapour Pressure | 1.93E-14mmHg at 25°C |
| Index of Refraction | 1.658 |