77500-04-0

77500-04-0 structure

Name: MeIQx
Chemical Name: MeIQx
CAS Number: 77500-04-0
Molecular Formula: C₁₁H₁₁N₅
Molecular Weight: 213.23900
Catalog: Research Areas Cancer
Create Date: 2018-11-23 09:30:22
Modify Date: 2026-07-02 13:10:23
MeIQx, a dietary aromatic amine, is mutagenic compound could be isolated from present in fried beef and beef extracts. MeIQx binds covalently to hemoglobin. MeIQx induces liver tumors[1][2].

Name	MeIQx
Synonyms	3H-Imidazo(4,5-F)quinoxalin-2-amine, 3,8-dimethyl Ccris MEIQX 2-AMINO-3,8-DIMETHYLIMIDAZO[4,5-F]QUINOXALINE 3,8-Dimethyl-3H-Imidazo[4,5-f]quinoxalin-2-amine MeIQx, Mutagenic agent 3,8-dimethyl-3H-imidazo<quinoxalin-2-amine 1-Methyl-2-amino-4,5-(2-methyl-1,4-diaza-1,3-butadiene-1,4-diyl)-1H-benzimidazole 8-Methyl-iqx 8-Methyl-IQX 8-MeIQX 3,8-dimethylimidazo[4,5-f]quinoxalin-2-amine 2-amino-3,8-dimethyl-3h-imidazo(4,5-f)quinoxaline MelQx 5-f)quinoxaline,2-amino-3,8-dimethyl-3h-imidazo( 3H-Imidazo(4,5-f)quinoxaline, 2-amino-3,8-dimethyl Brn MelQx (2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline

Description	MeIQx, a dietary aromatic amine, is mutagenic compound could be isolated from present in fried beef and beef extracts. MeIQx binds covalently to hemoglobin. MeIQx induces liver tumors[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	MeIQx (0.47 mM; 0-120 min) binds covalently to mouse hemoglobin and is activated by mouse microsomes to metabolites[1].
In Vivo	MeIQx (2.0-200 mg/kg; i.p.; male Swiss Webster mice) is in the covalent binding to hemoglobin in a dose-dependent manner[1]. Animal Model: Male Swiss Webster mice[1] Dosage: 2.0-200 mg/kg Administration: Intraperitoneal injection Result: Increased the covalent binding to hemoglobin in a dose-dependent manner.

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Sense Organs and Special Senses (Ear) - effect, not otherwise specified Liver - tumors

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Blood - leukemia

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 118,91,1983 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 56,211,1993 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 40,283,1986 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 40,283,1986 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 56,211,1993 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 56,211,1993

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%