Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Zolimidine
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Purity: 98.0%
Stocking Period: 10 Day
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DC Chemicals Limited
China
Product Name: Zolimidine
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Stocking Period: 10 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: zolimidine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

1222-57-7

1222-57-7 structure

Name: 2-(4-methylsulfonylphenyl)imidazo[1,2-a]pyridine
Chemical Name: 2-(4-methylsulfonylphenyl)imidazo[1,2-a]pyridine
CAS Number: 1222-57-7
Molecular Formula: C₁₄H₁₂N₂O₂S
Molecular Weight: 272.32
Create Date: 2018-08-20 20:36:48
Modify Date: 2024-01-09 09:23:48
Zolimidine, a derivate of imidazopyridine, is an orally active antiulcer agent. Zolimidine stimulates mucus secretion in intestinal mucosal cells and enhacnes intestinal wall more resistant to ulceration. Zolimidine exhibits gastroprotective effect in duodenal ulcer research[1][2].

Name	2-(4-methylsulfonylphenyl)imidazo[1,2-a]pyridine
Synonyms	Zolimidine Zolimidin EINECS 214-947-4

Description	Zolimidine, a derivate of imidazopyridine, is an orally active antiulcer agent. Zolimidine stimulates mucus secretion in intestinal mucosal cells and enhacnes intestinal wall more resistant to ulceration. Zolimidine exhibits gastroprotective effect in duodenal ulcer research[1][2].
Related Catalog	Research Areas >> Endocrinology Signaling Pathways >> Others >> Others
In Vivo	Zolimidine (200 mg/kg；口服) 降低由 Indomethacin (HY-14397) (5 mg/kg/天，持续 8 天，直肠) 诱导的大鼠肠道溃疡的发生率[2]。Zolimidine (加在饮食中；1% 含量) 可降低豚鼠由角叉菜胶 (加在饮用水中；5% 含量，持续 40 天) 引起的肠溃疡的发生率[2]。
References	[1]. Belohlavek D, et al. The effect of zolimidine, imidazopyridine-derivate, on the duodenal ulcer healing. Scand J Gastroenterol Suppl. 1979;54:44. [2]. Carminati GM, et al. Protective action of zolimidine against two different types of experimental intestinal ulcers. Farmaco, Edizione Pratica (1978), 33(2), 68-79.

Density	1.31 g/cm3
Molecular Formula	C₁₄H₁₂N₂O₂S
Molecular Weight	272.32
Exact Mass	272.06200
PSA	59.82000
LogP	3.48560
Index of Refraction	1.653

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NJ5758500

CHEMICAL NAME :: Imidazo(1,2-a)pyridine, 2-(p-(methylsulfonyl)phenyl)-

CAS REGISTRY NUMBER :: 1222-57-7

BEILSTEIN REFERENCE NO. :: 0752451

LAST UPDATED :: 199712

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C14-H12-N2-O2-S

MOLECULAR WEIGHT :: 272.34

WISWESSER LINE NOTATION :: T56 AN DNJ CR DSW1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3710 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #3318880

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 950 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 33,1655,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FMXXAJ French Medicament Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Discontinued. Volume(issue)/page/year: #8177M

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 765 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FMXXAJ French Medicament Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Discontinued. Volume(issue)/page/year: #8177M

HS Code	2933990090

2076-70-2

~68%

1222-57-7

Literature: He, Chuan; Hao, Jing; Xu, Huan; Mo, Yiping; Liu, Huiying; Han, Juanjuan; Lei, Aiwen Chemical Communications (Cambridge, United Kingdom), 2012 , vol. 48, # 90 p. 11073 - 11075,3 Title/Abstract Full Text Show Details He, Chuan; Hao, Jing; Xu, Huan; Mo, Yiping; Liu, Huiying; Han, Juanjuan; Lei, Aiwen Chemical Communications, 2012 , vol. 48, # 90 p. 11073 - 11075

110-86-1

1562372-99-9

~84%

1222-57-7

Literature: Yu, Jipan; Jin, Yunhe; Zhang, Hao; Yang, Xiaobo; Fu, Hua Chemistry - A European Journal, 2013 , vol. 19, # 49 p. 16804 - 16808

504-29-0

56041-85-1

1222-57-7

100-68-5

1222-57-7

Literature: Mohan, Darapaneni Chandra; Donthiri, Ramachandra Reddy; Rao, Sadu Nageswara; Adimurthy, Subbarayappa Advanced Synthesis and Catalysis, 2013 , vol. 355, # 11-12 p. 2217 - 2221

504-29-0

10297-73-1

~92%

1222-57-7

Literature: Zhang, Yuhong; Zhang, Yuanfei; Chen, Zhengkai; Wu, Wenliang; Su, Weiping Journal of Organic Chemistry, 2013 , vol. 78, # 24 p. 12494 - 12504

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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