Copper??Catalyzed Aerobic Oxidative C H Functionalization of Substituted Pyridines: Synthesis of Imidazopyridine Derivatives

J Yu, Y Jin, H Zhang, X Yang…

Index: Yu, Jipan; Jin, Yunhe; Zhang, Hao; Yang, Xiaobo; Fu, Hua Chemistry - A European Journal, 2013 , vol. 19, # 49 p. 16804 - 16808

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Abstract

Abstract A novel, efficient, and practical method for the synthesis of imidazopyridine derivatives has been developed through the copper-catalyzed aerobic oxidative C [BOND] H functionalization of substituted pyridines with N-(alkylidene)-4H-1, 2, 4-triazol-4-amines. The procedure occurs by cleavage of the N [BOND] N bond in the N-(alkylidene)-4H-1, 2, 4- triazol-4-amines and activation of an aryl C [BOND] H bond in the substituted pyridines. ...