208706-12-1

208706-12-1 structure

Name: (1R,1'S,3'R/1R,1'R,3'S)-L-054,264
Chemical Name: N-[1-(cyclohexylmethylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl]spiro[indene-1,4'-piperidine]-1'-carboxamide
CAS Number: 208706-12-1
Molecular Formula: C₃₃H₄₁N₅O₂
Molecular Weight: 539.71
Catalog: Signaling Pathways GPCR/G Protein Somatostatin Receptor
Create Date: 2017-09-03 16:41:30
Modify Date: 2024-09-14 18:00:23
(1R,1'S,3'R/1R,1'R,3'S)-L-054,264 is a selective non-peptide human somatostatin receptor subtype 2 (sst2) agonist. (1R,1'S,3'R/1R,1'R,3'S)-L-054,264 can be used in the study of retinal neuromodulation[1][2].

Name	N-[1-(cyclohexylmethylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl]spiro[indene-1,4'-piperidine]-1'-carboxamide

Description	(1R,1'S,3'R/1R,1'R,3'S)-L-054,264 is a selective non-peptide human somatostatin receptor subtype 2 (sst2) agonist. (1R,1'S,3'R/1R,1'R,3'S)-L-054,264 can be used in the study of retinal neuromodulation[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Somatostatin Receptor Research Areas >> Neurological Disease
References	[1]. Yang L, et al. Spiro[1H-indene-1,4'-piperidine] derivatives as potent and selective non-peptide human somatostatin receptor subtype 2 (sst2) agonists. J Med Chem. 1998 Jun 18;41(13):2175-9. [2]. Weir K, et al. A potential role for somatostatin signaling in regulating retinal neurogenesis. Sci Rep. 2021 May 26;11(1):10962. doi: 10.1038/s41598-021-90554-3. Erratum in: Sci Rep. 2021 Aug 16;11(1):16948.