(1R,1'S,3'R/1R,1'R,3'S)-L-054,264

Modify Date: 2025-08-27 19:32:20

(1R,1'S,3'R/1R,1'R,3'S)-L-054,264 structure	Common Name	(1R,1'S,3'R/1R,1'R,3'S)-L-054,264
	CAS Number	208706-12-1	Molecular Weight	539.71
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₃H₄₁N₅O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of (1R,1'S,3'R/1R,1'R,3'S)-L-054,264

(1R,1'S,3'R/1R,1'R,3'S)-L-054,264 is a selective non-peptide human somatostatin receptor subtype 2 (sst2) agonist. (1R,1'S,3'R/1R,1'R,3'S)-L-054,264 can be used in the study of retinal neuromodulation[1][2].

Name	N-[1-(cyclohexylmethylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl]spiro[indene-1,4'-piperidine]-1'-carboxamide

Description	(1R,1'S,3'R/1R,1'R,3'S)-L-054,264 is a selective non-peptide human somatostatin receptor subtype 2 (sst2) agonist. (1R,1'S,3'R/1R,1'R,3'S)-L-054,264 can be used in the study of retinal neuromodulation[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Somatostatin Receptor Research Areas >> Neurological Disease
References	[1]. Yang L, et al. Spiro[1H-indene-1,4'-piperidine] derivatives as potent and selective non-peptide human somatostatin receptor subtype 2 (sst2) agonists. J Med Chem. 1998 Jun 18;41(13):2175-9. [2]. Weir K, et al. A potential role for somatostatin signaling in regulating retinal neurogenesis. Sci Rep. 2021 May 26;11(1):10962. doi: 10.1038/s41598-021-90554-3. Erratum in: Sci Rep. 2021 Aug 16;11(1):16948.

Description

Related Catalog

Signaling Pathways >> GPCR/G Protein >> Somatostatin Receptor

Research Areas >> Neurological Disease

References

[1]. Yang L, et al. Spiro[1H-indene-1,4'-piperidine] derivatives as potent and selective non-peptide human somatostatin receptor subtype 2 (sst2) agonists. J Med Chem. 1998 Jun 18;41(13):2175-9.

[2]. Weir K, et al. A potential role for somatostatin signaling in regulating retinal neurogenesis. Sci Rep. 2021 May 26;11(1):10962. doi: 10.1038/s41598-021-90554-3. Erratum in: Sci Rep. 2021 Aug 16;11(1):16948.

Molecular Formula	C₃₃H₄₁N₅O₂
Molecular Weight	539.71
Exact Mass	539.32600
PSA	103.25000
LogP	6.15050
InChIKey	DAMXHAMKVXERLM-UHFFFAOYSA-N
SMILES	NCC1CCCC(CNC(=O)C(Cc2c[nH]c3ccccc23)NC(=O)N2CCC3(C=Cc4ccccc43)CC2)C1

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Product Name: （1R，1'S，3'R / 1R，1'R，3'S）-L-054,264
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(1R,1'S,3'R/1R,1'R,3'S)-L-054,264 Biological Activity

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