261619-50-5

261619-50-5 structure

Name: CGS 35066
Chemical Name: CGS 35066,α-[(S)-(Phosphonomethyl)amino]-3-dibenzofuranpropanoicacid
CAS Number: 261619-50-5
Molecular Formula: C₁₆H₁₆NO₆P
Molecular Weight: 349.27500
Catalog: Research Areas Cardiovascular Disease
Create Date: 2017-07-04 11:49:59
Modify Date: 2024-01-13 17:29:05
CGS35066 is a potent and selective aminophosphonate inhibitor of endothelin-converting enzyme-1 (ECE-1). CGS 35066 inhibits the activity of human ECE-1 and rat kidney neutral endopeptidase 24.11 (NEP) in vitro with IC50 values of 22 nM and 2.3 μM, respectively[1].

Name	CGS 35066,α-[(S)-(Phosphonomethyl)amino]-3-dibenzofuranpropanoicacid
Synonyms	Gisadenafil besylate

Description	CGS35066 is a potent and selective aminophosphonate inhibitor of endothelin-converting enzyme-1 (ECE-1). CGS 35066 inhibits the activity of human ECE-1 and rat kidney neutral endopeptidase 24.11 (NEP) in vitro with IC50 values of 22 nM and 2.3 μM, respectively[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others
References	[1]. A J Trapani, et al. Pharmacological properties of CGS 35066, a potent and selective endothelin-converting enzyme inhibitor, in conscious rats. J Cardiovasc Pharmacol. 2000 Nov;36(5 Suppl 1):S40-3.