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13027-33-3

13027-33-3 structure
13027-33-3 structure
  • Name: 3β,5α-Dihydroxycholestan-6-one
  • Chemical Name: 5alpha-cholestan-3beta,5alpha-diol-6-one
  • CAS Number: 13027-33-3
  • Molecular Formula: C27H46O3
  • Molecular Weight: 418.652
  • Catalog: Research Areas Cardiovascular Disease
  • Create Date: 2018-02-13 08:00:00
  • Modify Date: 2024-01-12 08:34:59
  • 5α-Hydroxy-6-keto cholesterol is major metabolite of β-epoxide (5α,6β-epoxycholesterol) during direct exposure of intact cultured human bronchial epithelial cells (16-HBE) to ozone. 5α-Hydroxy-6-keto cholesterol inhibits cholesterol synthesis with an IC50 of 350 nM[1].

Name 5alpha-cholestan-3beta,5alpha-diol-6-one
Synonyms CHOLESTANE-6-OXO-3,5-DIOL
Cholestan-6-one, 3,5-dihydroxy-, (3β,5α)-
(3β,5α)-3,5-Dihydroxycholestan-6-one
CHOLESTANE-6-OXO-3BETA,5ALPHA-DIOL
5ALPHA-HYDROXY-6-KETO CHOLESTEROL
YS-64
yakkasterone
3β,5α-Dihydroxycholestan-6-one
Description 5α-Hydroxy-6-keto cholesterol is major metabolite of β-epoxide (5α,6β-epoxycholesterol) during direct exposure of intact cultured human bronchial epithelial cells (16-HBE) to ozone. 5α-Hydroxy-6-keto cholesterol inhibits cholesterol synthesis with an IC50 of 350 nM[1].
Related Catalog
In Vitro 5α-Hydroxy-6-keto cholesterol (0.01, 0.1, 1, 10 μM) is cytotoxic to cultured 16-HBE cells[1].
References

[1]. Melissa K Pulfer, et al. Formation of biologically active oxysterols during ozonolysis of cholesterol present in lung surfactant. J Biol Chem. 2004 Jun 18;279(25):26331-8.

Density 1.1±0.1 g/cm3
Boiling Point 528.9±45.0 °C at 760 mmHg
Molecular Formula C27H46O3
Molecular Weight 418.652
Flash Point 287.7±25.2 °C
Exact Mass 418.344696
PSA 57.53000
LogP 7.00
Vapour Pressure 0.0±3.2 mmHg at 25°C
Index of Refraction 1.531