328232-95-7
328232-95-7 structure
- Name: MK 0557
- Chemical Name: N-[1-(2-fluorophenyl)pyrazol-3-yl]-1'-oxospiro[cyclohexane-4,3'-furo[3,4-c]pyridine]-1-carboxamide
- CAS Number: 328232-95-7
- Molecular Formula: C22H19FN4O3
- Molecular Weight: 406.41000
- Catalog: Signaling Pathways GPCR/G Protein Neuropeptide Y Receptor
- Create Date: 2016-03-25 20:12:15
- Modify Date: 2024-01-11 18:40:41
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MK-0557 is a highly selective, orally available neuropeptide Y5 receptor antagonist with a Ki of 1.6 nM.
| Name | N-[1-(2-fluorophenyl)pyrazol-3-yl]-1'-oxospiro[cyclohexane-4,3'-furo[3,4-c]pyridine]-1-carboxamide |
|---|---|
| Synonyms |
UNII-HVE36P8422
MK-0557 1'-cyclohexane]-4'-carboxamide MK 0557 |
| Description | MK-0557 is a highly selective, orally available neuropeptide Y5 receptor antagonist with a Ki of 1.6 nM. |
|---|---|
| Related Catalog | |
| Target |
Ki: 1.6 nM (Y5)[1] |
| In Vitro | MK-0557 antagonizes the effects of the NPY5R-selective agonist on body-weight gain and hyperphagia in C57BL/6J mice and significantly suppresses the body-weight gain in diet-induced obese (DIO) mice. When lean mice on regular chow are switched to a medium high-fat diet (4.2 kcal/g) and treated with MK-0557 at 30 mg/kg PO QD, MK-0557 causes a 40% reduction inbody-weight gain at day 35[2]. |
| References |
| Molecular Formula | C22H19FN4O3 |
|---|---|
| Molecular Weight | 406.41000 |
| Exact Mass | 406.14400 |
| PSA | 89.34000 |
| LogP | 3.02290 |
| Storage condition | 2-8℃ |
| Precursor 6 | |
|---|---|
| DownStream 0 | |