DC Chemicals Limited
China
Product Name: ML354
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: CHEMBRDG-BB 5280909
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

89159-60-4

89159-60-4 structure

89159-60-4 structure

Name: ML 354
Chemical Name: (1-methyl-5-nitro-3-phenylindol-2-yl)methanol
CAS Number: 89159-60-4
Molecular Formula: C₁₆H₁₄N₂O₃
Molecular Weight: 282.29400
Catalog: Signaling Pathways GPCR/G Protein Protease-Activated Receptor (PAR)
Create Date: 2017-11-18 06:55:34
Modify Date: 2024-01-10 12:54:18
ML354 is a selective PAR4 antagonist with an IC50 of 140 nM[1].

Name	(1-methyl-5-nitro-3-phenylindol-2-yl)methanol
Synonyms	1-methyl-2-hydroxymethyl-3-phenyl-5-nitroindole 1h-indole-2-methanol,1-methyl-5-nitro-3-phenyl

Description	ML354 is a selective PAR4 antagonist with an IC50 of 140 nM[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> GPCR/G Protein >> Protease-Activated Receptor (PAR)
References	[1]. Wen W, et al. Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists: Discovery and SAR of ML354. Bioorg Med Chem Lett. 2014 Oct 1;24(19):4708-4713.

Density	1.29g/cm3
Boiling Point	544ºC at 760 mmHg
Molecular Formula	C₁₆H₁₄N₂O₃
Molecular Weight	282.29400
Flash Point	282.8ºC
Exact Mass	282.10000
PSA	70.98000
LogP	3.76900
Index of Refraction	1.646

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301
Precautionary Statements	Missing Phrase - N15.00950417
RIDADR	UN 2811 6.1 / PGIII
HS Code	2933990090

89173-89-7 structure

89173-89-7

~74%

89159-60-4 structure

89159-60-4

Literature: Grinev, A. I.; Krichevskii, E. S.; Romanova, O. B.; Filipenko, T. Ya.; Polezhaeva, A. I. Pharmaceutical Chemistry Journal, 1983 , vol. 17, # 9 p. 635 - 642 Khimiko-Farmatsevticheskii Zhurnal, 1983 , vol. 17, # 9 p. 1066 - 1072

41018-87-5 structure

41018-87-5

~%

89159-60-4 structure

89159-60-4

Literature: Grinev, A. I.; Krichevskii, E. S.; Romanova, O. B.; Filipenko, T. Ya.; Polezhaeva, A. I. Pharmaceutical Chemistry Journal, 1983 , vol. 17, # 9 p. 635 - 642 Khimiko-Farmatsevticheskii Zhurnal, 1983 , vol. 17, # 9 p. 1066 - 1072

68285-93-8 structure

68285-93-8

~%

89159-60-4 structure

89159-60-4

Literature: Grinev, A. I.; Krichevskii, E. S.; Romanova, O. B.; Filipenko, T. Ya.; Polezhaeva, A. I. Pharmaceutical Chemistry Journal, 1983 , vol. 17, # 9 p. 635 - 642 Khimiko-Farmatsevticheskii Zhurnal, 1983 , vol. 17, # 9 p. 1066 - 1072

70063-29-5 structure

70063-29-5

~%

89159-60-4 structure

89159-60-4

Literature: Grinev, A. I.; Krichevskii, E. S.; Romanova, O. B.; Filipenko, T. Ya.; Polezhaeva, A. I. Pharmaceutical Chemistry Journal, 1983 , vol. 17, # 9 p. 635 - 642 Khimiko-Farmatsevticheskii Zhurnal, 1983 , vol. 17, # 9 p. 1066 - 1072

Precursor 4
89173-89-7 41018-87-5 68285-93-8 70063-29-5
DownStream 2
84858-14-0 84858-15-1

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%