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25514-31-2

25514-31-2 structure
25514-31-2 structure
  • Name: Bruceine A
  • Chemical Name: brucein a
  • CAS Number: 25514-31-2
  • Molecular Formula: C26H34O11
  • Molecular Weight: 522.542
  • Catalog: Signaling Pathways Anti-infection Parasite
  • Create Date: 2018-09-03 17:20:32
  • Modify Date: 2025-08-20 20:36:19
  • Bruceine A(NSC310616; Dihydrobrusatol) is a natural quassinoid compound extracted from the dried fruits of Brucea javanica (L.); are potential candidates for the treatment of canine babesiosis.IC50 value:Target: Bruceine A inhibited the in vitro growth of Babesia gibsoni in canine erythrocytes at lower concentration compared with the standard antibabesial drug diminazene aceturate and killed the parasites within 24 hr at a concentration of 25 nM. Oral administration of bruceine A at a dosage of 6.4 mg/kg/day for 5 days resulted in no clinical findings in a dog with normal ranges of hematological and biochemical values in the blood. Three dogs were infected with B. gibsoni and two of them were treated with bruceine A at a dosage of 6.4 mg/kg/day for 6 days from day 5 post-infection.
Name brucein a
Synonyms Bruceine A
BRUCEIN A
Methyl (11β,12α,13β,15β)-3,11,12-trihydroxy-15-[(3-methylbutanoyl)oxy]-2,16-dioxo-13,20-epoxypicras-3-en-21-oate
Picras-3-en-21-oic acid, 13,20-epoxy-3,11,12-trihydroxy-15-(3-methyl-1-oxobutoxy)-2,16-dioxo-, methyl ester, (11β,12α,13β,15β)-
Isobruceine A
22,23-dihydrobrusatol
Description Bruceine A(NSC310616; Dihydrobrusatol) is a natural quassinoid compound extracted from the dried fruits of Brucea javanica (L.); are potential candidates for the treatment of canine babesiosis.IC50 value:Target: Bruceine A inhibited the in vitro growth of Babesia gibsoni in canine erythrocytes at lower concentration compared with the standard antibabesial drug diminazene aceturate and killed the parasites within 24 hr at a concentration of 25 nM. Oral administration of bruceine A at a dosage of 6.4 mg/kg/day for 5 days resulted in no clinical findings in a dog with normal ranges of hematological and biochemical values in the blood. Three dogs were infected with B. gibsoni and two of them were treated with bruceine A at a dosage of 6.4 mg/kg/day for 6 days from day 5 post-infection.
Related Catalog
References

[1]. Nakao R, et al. Evaluation of efficacy of bruceine A, a natural quassinoid compound extracted from a medicinal plant, Brucea javanica, for canine babesiosis. J Vet Med Sci. 2009 Jan;71(1):33-41.
Density 1.4±0.1 g/cm3
Boiling Point 712.6±60.0 °C at 760 mmHg
Molecular Formula C26H34O11
Molecular Weight 522.542
Flash Point 237.1±26.4 °C
Exact Mass 522.210083
PSA 165.89000
LogP 1.80
Vapour Pressure 0.0±5.2 mmHg at 25°C
Index of Refraction 1.596
Storage condition -20°C
Precursor  1

DownStream  0

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