Bruceine A

Modify Date: 2025-08-20 20:36:19

Bruceine A Structure
Bruceine A structure
 Common Name Bruceine A
CAS Number 25514-31-2 Molecular Weight 522.542
Density 1.4±0.1 g/cm3 Boiling Point 712.6±60.0 °C at 760 mmHg
Molecular Formula C26H34O11 Melting Point N/A
MSDS N/A Flash Point 237.1±26.4 °C

 Use of Bruceine A


Bruceine A(NSC310616; Dihydrobrusatol) is a natural quassinoid compound extracted from the dried fruits of Brucea javanica (L.); are potential candidates for the treatment of canine babesiosis.IC50 value:Target: Bruceine A inhibited the in vitro growth of Babesia gibsoni in canine erythrocytes at lower concentration compared with the standard antibabesial drug diminazene aceturate and killed the parasites within 24 hr at a concentration of 25 nM. Oral administration of bruceine A at a dosage of 6.4 mg/kg/day for 5 days resulted in no clinical findings in a dog with normal ranges of hematological and biochemical values in the blood. Three dogs were infected with B. gibsoni and two of them were treated with bruceine A at a dosage of 6.4 mg/kg/day for 6 days from day 5 post-infection.

 Names

Name brucein a
Synonym More Synonyms

 Bruceine A Biological Activity

Description Bruceine A(NSC310616; Dihydrobrusatol) is a natural quassinoid compound extracted from the dried fruits of Brucea javanica (L.); are potential candidates for the treatment of canine babesiosis.IC50 value:Target: Bruceine A inhibited the in vitro growth of Babesia gibsoni in canine erythrocytes at lower concentration compared with the standard antibabesial drug diminazene aceturate and killed the parasites within 24 hr at a concentration of 25 nM. Oral administration of bruceine A at a dosage of 6.4 mg/kg/day for 5 days resulted in no clinical findings in a dog with normal ranges of hematological and biochemical values in the blood. Three dogs were infected with B. gibsoni and two of them were treated with bruceine A at a dosage of 6.4 mg/kg/day for 6 days from day 5 post-infection.
Related Catalog
References

[1]. Nakao R, et al. Evaluation of efficacy of bruceine A, a natural quassinoid compound extracted from a medicinal plant, Brucea javanica, for canine babesiosis. J Vet Med Sci. 2009 Jan;71(1):33-41.

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 712.6±60.0 °C at 760 mmHg
Molecular Formula C26H34O11
Molecular Weight 522.542
Flash Point 237.1±26.4 °C
Exact Mass 522.210083
PSA 165.89000
LogP 1.80
Vapour Pressure 0.0±5.2 mmHg at 25°C
Index of Refraction 1.596
InChIKey LPZSTPCYWWRQFU-VILODJCFSA-N
SMILES COC(=O)C12OCC34C(CC5C(C)=C(O)C(=O)CC5(C)C3C(O)C1O)OC(=O)C(OC(=O)CC(C)C)C24
Storage condition -20°C

 Precursor & DownStream

Precursor  1

DownStream  0

 Bruceine ABioassay

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Name: Cytotoxicity against human Lu1 cells after 2 days by sulforhodamine B assay
Source: ChEMBL
Target: Lu1
External Id: CHEMBL965751
Name: Cytotoxicity against hormone-dependent human LNCAP cells after 2 days by sulforhodami...
Source: ChEMBL
Target: LNCaP
External Id: CHEMBL965752
Name: Antimalarial activity against multidrug-resistant Plasmodium falciparum K1 infected h...
Source: ChEMBL
Target: Plasmodium falciparum
External Id: CHEMBL1019090
Name: Cytotoxicity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay
Source: ChEMBL
Target: MDA-MB-231
External Id: CHEMBL4712370
Name: Cytotoxicity against human MCF-7 cells incubated for 72 hrs by MTT assay
Source: ChEMBL
Target: MCF7
External Id: CHEMBL4712369
Name: Antibabesial activity against Babesia gibsoni
Source: ChEMBL
Target: Babesia gibsoni
External Id: CHEMBL925693
Name: Antimalarial activity as reduced parasitaemia at day 4 against Plasmodium berghei N i...
Source: ChEMBL
Target: Plasmodium berghei
External Id: CHEMBL1019093
Name: Antiamoebic activity against Entamoeba histolytica
Source: ChEMBL
Target: Entamoeba histolytica
External Id: CHEMBL3058937
Name: Ratio ED50 for human MCF7 cells to ED50 for human MCF7 cells in presence of 43 uM (-)...
Source: ChEMBL
Target: MCF7
External Id: CHEMBL965755
Name: Antimalarial activity as reduced parasitaemia at day 4 against Plasmodium berghei N i...
Source: ChEMBL
Target: Plasmodium berghei
External Id: CHEMBL1019092
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 Synonyms

Bruceine A
BRUCEIN A
Methyl (11β,12α,13β,15β)-3,11,12-trihydroxy-15-[(3-methylbutanoyl)oxy]-2,16-dioxo-13,20-epoxypicras-3-en-21-oate
Isobruceine A
22,23-dihydrobrusatol
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