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533884-09-2

533884-09-2 structure
533884-09-2 structure
  • Name: LY500307
  • Chemical Name: (3aS,4R,9bR)-4-(4-hydroxyphenyl)-1,2,3,3a,4,9b-hexahydrocyclopenta[c]chromen-8-ol
  • CAS Number: 533884-09-2
  • Molecular Formula: C18H18O3
  • Molecular Weight: 282.33
  • Catalog: Biochemical Inhibitor Endocrinology & Hormones Estrogen/progestogen Receptor agonist
  • Create Date: 2018-12-18 10:21:05
  • Modify Date: 2024-01-31 19:28:43
  • Erteberel (LY500307) is a potent and selective estrogen receptor beta (ERβ) inhibitor with Ki and EC50 of 1.54 nM and 3.61 nM, respectively[1]. Anti-tumor activities[2].

Name (3aS,4R,9bR)-4-(4-hydroxyphenyl)-1,2,3,3a,4,9b-hexahydrocyclopenta[c]chromen-8-ol
Synonyms Erteberel
(3aS,4R,9bR)-4-(4-Hydroxyphenyl)-1,2,3,3a,4,9b-hexahydrocyclopenta[c]chromen-8-ol
Benzo[b]cyclopenta[d]pyran-8-ol, 1,2,3,3a,4,9b-hexahydro-4-(4-hydroxyphenyl)-, (3aS,4R,9bR)-
(3aS,4R,9bR)-1,2,3,3a,4,9b-Hexahydro-4-(4-hydroxyphenyl)cyclopenta[c][1]benzopyran-8-ol
LY500307
Description Erteberel (LY500307) is a potent and selective estrogen receptor beta (ERβ) inhibitor with Ki and EC50 of 1.54 nM and 3.61 nM, respectively[1]. Anti-tumor activities[2].
Related Catalog
Target

Ki: 1.54 nM (ERβ)[1] EC50: 3.61 nM[1]

In Vitro Treatment with LY500307 significantly reduces the proliferation of GBM cells with no activity on normal astrocytes in vitro[2]. ERβ agonists promote apoptosis of GBM cells. It modulated several pathways related to apoptosis, cell cycle, and DNA damage response[2]. LY500307 sensitizes GBM cells to several FDA-approved chemotherapeutic drugs including cisplatin, lomustine and temozolomide[2].
In Vivo LY500307 treatment significantly reduces tumor growth and promotes apoptosis of GBM tumors in an orthotopic model[2]. LY500307 treatment improves the overall survival of tumor-bearing mice in the GL26 syngeneic glioma model[2].
References

[1]. Zhao L, et al. Pharmacological activation of estrogen receptor beta augments innate immunity to suppress cancer metastasis. Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):E3673-E3681.

[2]. Sareddy GR, et al. Selective Estrogen Receptor β Agonist LY500307 as a Novel Therapeutic Agent for Glioblastoma. Sci Rep. 2016 Apr 29;6:24185.

Density 1.268
Boiling Point 485.2±45.0 °C at 760 mmHg
Molecular Formula C18H18O3
Molecular Weight 282.33
Flash Point 247.3±28.7 °C
Exact Mass 282.125580
PSA 49.69000
LogP 3.84
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.639
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