An inhibitor is a substance that blocks chemical reactions, biological reactions (including immune reactions), and biological activities. Currently commonly used inhibitors include: immunosuppressants and enzyme inhibitors. 1. Immunosuppressants: Immunosuppressive drugs that lower the immune response. It can selectively act on certain immune reaction links and immune cells required for inhibition. Immunity refers to the body's response to various pathogenic substances. Some of these reactions are beneficial to the body and can enhance the body's disease resistance. Some are unfavorable to the body and can cause physiological disorders or tissue damage (allergy). Therefore, the immune response of the body is reduced by applying an immunosuppressive agent to an allergic reaction to the body to affect the immune process. In order to treat various immune diseases and to attenuate tissue incompatibility, various immunosuppressive agents have been developed, some of which have been widely used in the clinic. Commonly used immunosuppressive agents are glucocorticoids (prednisone, prednisolone, etc.), alkylating agents (nitrogen oxide mustard, cyclophosphamide, thiotepa, busulfan, etc.), antimetabolites (6- Mercaptopurine, azathioprine, methotrexate, etc.). Although the mechanism of action of immunosuppressive agents is not completely clear, it has the following characteristics: 1 Most immunosuppressive agents can inhibit both cellular immunity and humoral immunity, and can be used for organ transplantation and autoimmune diseases. 2 The inhibitory effect on the primary immune response is strong, and the effect on the re-immune response is weak. 3 can act on both pathological and normal immunity, and therefore often leads to certain complications. 4 These drugs are highly toxic and have serious adverse reactions. 2. Enzyme inhibitor: An enzyme inhibitor is a compound or drug that binds to an enzyme and inhibits the catalytic activity of the enzyme. Clinically, an enzyme inhibitor specifically interferes with a metabolic system to achieve therapeutic goals. For example, a monoamine oxidase inhibitor used as an antidepressant, a carbonic anhydrase inhibitor used as a diuretic, a dopa decarboxylase inhibitor for antihypertensive drugs, and a penicillin or cephalosporin belonging to a cell wall synthetase inhibitor among antibiotics. Classes, etc. It is also used in veterinary medicine and agriculture. In addition, enzyme inhibitors can also be used to study the mechanism of action and metabolic pathways. The structure of the enzyme inhibitor is often similar to the structure of its natural substrate. According to the modification of the natural substrate design inhibitor, the first step is to analyze and determine the function of each part of the molecule when combined with the enzyme, whether it is a combination, whether it is repulsive or not related to the binding. Secondly, the degree of tolerance of the binding site to adjacent steric hindrance is known. Each functional group is then substituted to regulate the strength of interaction with the enzyme. Enzyme inhibitors can be divided into two major categories of reversible and irreversible. (1) An inhibitor that binds to an enzyme through a non-covalent bond is a reversible inhibitor. (2) The inhibitor that binds to the enzyme through the covalent bond is an irreversible inhibitor, and the binding is very tight, and is not affected by changes in concentration such as dialysis or dilution after binding with the enzyme.


Amino compound >
Oxy-containing amino compound Cycloalkylamines, aromatic monoamines, aromatic polyamines and derivatives and salts thereof Acyclic monoamines, polyamines and their derivatives and salts Amide compound Sulfonic acid amino compound
Alcohols, phenols, phenolic compounds and derivatives >
2-cycloalcohol Halogenated, sulfonated, nitrated or nitrosated derivatives of alcohols Extremely halogenated, sulfonated, nitrated or nitrosated derivatives of phenols Phenol and its halogenated, sulfonated, nitrated or nitrosated derivatives Acyclic alcohol
Nitrogen-containing compound
Nitrile compound
Organic derivative of hydrazine or hydrazine
Terpenoid
Ether compounds and their derivatives >
Ether, ether alcohol Halogenation, sulfonation, nitration or nitrosation of ethers, ether alcohols, ether phenols
Aldehyde
Carboxylic compounds and derivatives >
Cyclic carboxylic acid Halogenation, sulfonation, nitration or nitrosation of carboxylic acids Halogenation, sulfonation, nitration or nitration of carboxylic anhydrides Carboxylic acid halide Carboxylic esters and their derivatives Salt of carboxylic acid ester and its derivatives Acyclic carboxylic acid
Hydrocarbon compounds and their derivatives >
Aromatic hydrocarbon Cyclic hydrocarbon Hydrocarbon sulfonate Hydrocarbon halide Hydrocarbon nitrite Acyclic hydrocarbon
Ketone compound
Alkyl ureas and their derivatives and salts
Inorganic acid ester
Heterocyclic compound
Diazo, azo or azo compound
Organosilicon compound
Organometallic compound >
Organic palladium Organic germanium, cobalt, strontium, barium, gallium, germanium, germanium, germanium, germanium, etc. Organic calcium Zirconium Organic potassium Organic Organic lithium Organic Organic aluminum Organotin Organic manganese Organic sodium Organic nickel Organic titanium Organic iron Organic copper Organotin Organic zinc Organic Organic Organic germanium, mercury, silver, platinum, etc. Organic germanium, antimony, bismuth, tungsten, antimony, bismuth, lead, vanadium, molybdenum, chromium, antimony, etc.
Organic sulfur compound
Organic phosphine compound
Organometallic salt
Organic fluorine compound >
Fluorobenzoic acid series Fluorobenzonitrile series Fluorobenzaldehyde series Fluorobenzyl alcohol series Fluoroanisole series Fluoroaniline series Fluorophenylacetic acid series Fluorophenol series Fluorobenzoic acid series Fluoronitrobenzene series Fluoropyridine series Potassium fluoroborate series Fluorobenzyl alcohol series Fluorotoluene series Fluorine red series Fluoroethane series Fluoropropane series
Respiratory medication >
Asthma Other respiratory medications Peony Antitussive
Hormone and endocrine-regulating drugs >
Birth control pills Pituitary hormone Estrogen and progestogen drugs Adrenocorticotropic drugs Gonadotropin Thyroid hormone and antithyroid drugs other Prostaglandins Adrenal corticosteroids Androgen and anabolic hormone drugs Pancreatic hormones and other blood sugar regulating drugs Treatment of male erectile dysfunction drugs
Antipyretic analgesics >
Non-steroidal anti-inflammatory drugs Antipyretic and analgesic Anti-migraine drug Anti-gout medicine Analgesic
Antiallergic >
Allergic reaction medium blocker Antihistamine
Antiparasitic drug >
Anti-amebiasis and anti-trichomoniasis drugs Antimalarial Resistance to filariasis and anti-leishmaniasis Anti-fungal medicine Anthelmintic Antiprotozoal Anthelmintic
Antibiotics >
Beta-lactamase inhibitor Aminoglycoside Macrolide drug Peptide Polyene Rifamycin Lincosamide Other antibiotics Penicillin Tetracycline Cephalosporin Amide alcohol Agricultural antibiotics
Antineoplastic agents >
Hormone antineoplastic agents Antimetabolite antineoplastic Antibiotic antineoplastic agents Anti-tumor adjuvant Other antineoplastic agents Natural source antineoplastic agents Alkylating agent Tinic antineoplastic agents Idiopathic pulmonary fibrosis (IPF) treatment
Anesthetic Agents >
Skeletal muscle relaxant Local anesthetics General anesthetics
Urinary system medication >
Diuretic Diabetes insipidus medication Other urinary system medication Dehydrated medicine
Other chemicals >
other Health and epidemic prevention drugs
Synthetic anti-infective drugs >
Sulfonamides and synergists Antiviral drugs Anti-tuberculosis leprosy Antihelium drug Antifungal drugs Quinolone Natural source anti-infectives Disinfectant antiseptic Nitrofuran
Nervous system medication >
2 sedative and hypnotics Antiepileptic and anticonvulsant Anxiolytic Antipsychotic Antidepressant, manic Anti-shock palsy Brain metabolism regulating drug Cholinergic Other nervous system medication Central stimulant Parkinson's syndrome
Water, electrolyte and acid-base balance regulator >
Electrolyte balance regulator Glucose drug Acid-base balance regulator
Vitamins and minerals >
Trace elements and mineral drugs Vitamin AD drugs Vitamin B drugs Vitamin C drugs Nutritional health medicine
Digestive system medication >
Liver disease medication Acid and gastric mucosal protective drugs Biliary medicine Other digestive system medication Appetite suppressant and other diet pills Gastrointestinal drug Gastrointestinal expectorant Laxative antidiarrheal Inhibition of gastric acid secretion Antiemetic emetic Digestive drug
Blood system medication >
Leukocyte proliferative drug Platelet proliferative drug Anticoagulant and antiplatelet drugs Anti-anemia drug Blood volume expander Hemostatic drug
Circulatory system medication >
Regulating blood lipids Prevention and treatment of angina pectoris Calcium channel blocker Anti-congestive heart failure medicine Antihypertensive drug Antiarrhythmic drug Anti-shock vasoactive drug Other circulatory system medication Angiotensin converting enzyme and receptor inhibitor Peripheral vasodilator Beta-adrenergic receptor blocker Treatment of chronic cardiac insufficiency Anti-atherosclerosis
Diagnostic medication >
Organ function test agent Image inspection medication
Special medicine >
Radioisotope Antidote Stomatology medication Dermatology medication Surgical medication Ophthalmic medication
Drugs that affect tissue metabolism
Feed drug additive
Anti-stress drug
Immune function drug >
Immunomodulatory drug Immunosuppressive drug
Veterinary drug raw materials
Inhibitor
Common amino acids and protein drugs
Nucleic acid drug
Enzymes and coenzymes
Inhibitor >
Immune inhibitor Protein tyrosine kinase Neuronal Signaling PI3K/Akt/mTOR inhibitor (PI3K/Akt/mTOR) Metabolism Cell Cycle Epigenetics Cytoskeletal Signaling Angiogenesis DNA damage Proteases Apoptosis Mitogen-activated protein kinase (MAPK) Endocrinology & Hormones G protein coupled receptor(GPCR & G Protein) Transmembrane Transporters Tyrosine protein kinase/signal transducer and transcriptional activator inhibitor (JAK/STAT) TGF-beta/Smad signaling pathway inhibitor (TGF-beta/Smad) Stem Cells & Wnt Signaling Paths (Stem Cells & Wnt) Nuclear transcription factor (NF-κB) Ubiquitin inhibitor Microbiology Autophagy lysosome (Autophagy)
Biological response modifier
Fatty drug
Amino acids and their derivatives >
Arginine derivatives Asparagine derivatives Aspartic acid derivative Cysteine derivative Glutamine derivative Glutamic acid derivative Glycine derivatives Histidine derivative Isoleucine derivative Leucine derivative Lysine derivative Methionine derivatives Phenylalanine derivatives Proline derivatives Serine derivative Threonine derivative Tryptophan derivatives Tyrosine derivatives Proline derivatives Alanine derivatives Methionine derivatives BOC-amino acid Cbz-amino acid FMOC-amino acid --amino acid Other protected amino acids Amino alcohol derivative Amino acid salt Ester amino acid Other amino acid derivatives Natural amino acids and their derivatives
Carbohydrate >
Monosaccharide Oligosaccharide Polysaccharide Double sugar
Biochemical reagent >
Biological dye Acid-base indicator Adjuvant
Nucleoside drugs >
Nucleoside intermediate Deoxynucleotides and their analogues Nucleotides and their analogues
Condensing agent
Peptide
Natural product
Plant extracts
Chinese herbal medicine ingredients
Microbiological reagent
Protein research
antibody >
Antibody Enzyme secondary antibody Apoptosis and autophagy Cell metabolism Chromatin / epigenetic / cell cycle Cytoskeleton/extracellular matrix MAPK and PI3K/Akt pathway Neuroscience Immunity and inflammation PKC, calcium ion and lipid signaling pathway Stem cells, development and differentiation Protein translation, folding and degradation Other categories of primary antibodies
  • CAS Number: 205678-31-5
  • MF: C22H24F3N3O4
  • MW: 451.44
  • Catalog:Integrin inhibitor
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 662.9±55.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 354.7±31.5 °C
  • CAS Number: 498-45-3
  • MF: C8H13NO2
  • MW: 155.194
  • Catalog:Adrenergic Receptor Agonist
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 281.3±40.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 123.9±27.3 °C
  • CAS Number: 928774-43-0
  • MF: C22H26N4O3
  • MW: 394.467
  • Catalog:Proton Pump inhibitor
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: N/A
  • Melting Point: 143-145°C
  • Flash Point: N/A
  • CAS Number: 139404-48-1
  • MF: C19H24BrNO5S2
  • MW: 490.432
  • Catalog:AChR antagonist
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: 218-220ºC
  • Flash Point: N/A
  • CAS Number: 913822-46-5
  • MF: C29H23N7O2S2
  • MW: 567.68400
  • Catalog:NF-κB inhibitor
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
  • CAS Number: 3801-06-7
  • MF: C24H31FO5
  • MW: 418.498
  • Catalog:Glucocorticoid Receptor Agonist
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 532.1±50.0 °C at 760 mmHg
  • Melting Point: 230-232°
  • Flash Point: 275.6±30.1 °C
  • CAS Number: 486424-20-8
  • MF: C21H23N7O3S
  • MW: 453.517
  • Catalog:GSK-3 inhibitor
  • Density: 1.4±0.1 g/cm3
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
  • CAS Number: 850879-09-3
  • MF: C23H21N5O3S
  • MW: 447.509
  • Catalog:Protein tyrosine kinase
  • Density: 1.4±0.1 g/cm3
  • Boiling Point: 649.5±65.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 346.6±34.3 °C
  • CAS Number: 136434-34-9
  • MF: C18H20ClNOS
  • MW: 333.875
  • Catalog:5-HT Receptor Inhibitor
  • Density: N/A
  • Boiling Point: 466.2ºC at 760 mmHg
  • Melting Point: 118-122ºC
  • Flash Point: 235.7ºC
  • CAS Number: 1255517-76-0
  • MF: C19H21F3N6
  • MW: 390.405
  • Catalog:S6 Kinase Inhibitor
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 572.8±50.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 300.2±30.1 °C
  • CAS Number: 1232410-49-9
  • MF: C18H16N4O3S
  • MW: 368.410
  • Catalog:ATM/ATR inhibitor
  • Density: 1.4±0.1 g/cm3
  • Boiling Point: 568.4±50.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 297.6±30.1 °C
  • CAS Number: 908115-27-5
  • MF: C25H30F3N5O4
  • MW: 521.532
  • Catalog:HSP eg HSP90 inhibitor
  • Density: 1.5±0.1 g/cm3
  • Boiling Point: 646.5±55.0 °C at 760 mmHg
  • Melting Point: 298-299℃
  • Flash Point: 344.8±31.5 °C
  • CAS Number: 143388-64-1
  • MF: C17H26ClN3O2S
  • MW: 371.925
  • Catalog:5-HT Receptor Agonist
  • Density: N/A
  • Boiling Point: 541.3ºC at760mmHg
  • Melting Point: 234-236ºC
  • Flash Point: 281.2ºC
  • CAS Number: 74150-27-9
  • MF: C19H18N4O2
  • MW: 334.372
  • Catalog:PDE inhibitor
  • Density: 1.4±0.1 g/cm3
  • Boiling Point: N/A
  • Melting Point: 249 °C(dec.)
  • Flash Point: N/A
  • CAS Number: 1173097-76-1
  • MF: C20H22N6OS2
  • MW: 426.558
  • Catalog:MEK inhibitor
  • Density: N/A
  • Boiling Point: 612.5ºC at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 324.2ºC
  • CAS Number: 91374-20-8
  • MF: C16H25ClN2O
  • MW: 296.836
  • Catalog:Dopamine Receptor Agonist
  • Density: N/A
  • Boiling Point: 410.5ºC at 760mmHg
  • Melting Point: 241-243ºC
  • Flash Point: N/A
  • CAS Number: 675576-97-3
  • MF: C30H30Cl2N4O4
  • MW: 581.490
  • Catalog:Mdm2 antagonist
  • Density: 1.4±0.1 g/cm3
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
  • CAS Number: 124431-80-7
  • MF: C23H30ClN7O6
  • MW: 535.981
  • Catalog:Adenosine Receptor Agonist
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: 204-206°C
  • Flash Point: N/A
  • CAS Number: 329710-24-9
  • MF: C10H4N6O
  • MW: 224.178
  • Catalog:Akt inhibitor
  • Density: 2.0±0.1 g/cm3
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
  • CAS Number: 153439-40-8
  • MF: C32H40ClNO4
  • MW: 538.117
  • Catalog:Histamine Receptor Inhibitor
  • Density: N/A
  • Boiling Point: N/A
  • Melting Point: 148-150oC
  • Flash Point: N/A
  • CAS Number: 841290-80-0
  • MF: C22H23FN6O5
  • MW: 470.454
  • Catalog:Syk inhibitor
  • Density: 1.4±0.1 g/cm3
  • Boiling Point: N/A
  • Melting Point: N/A
  • Flash Point: N/A
  • CAS Number: 1186486-62-3
  • MF: C31H36F6N6O2
  • MW: 638.647
  • Catalog:CETP inhibitor
  • Density: 1.4±0.1 g/cm3
  • Boiling Point: 680.1±65.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 365.1±34.3 °C
  • CAS Number: 959122-11-3
  • MF: C26H24N2O4
  • MW: 428.480
  • Catalog:Transferase inhibitor
  • Density: 1.3±0.1 g/cm3
  • Boiling Point: 576.1±50.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 302.2±30.1 °C
  • CAS Number: 841205-47-8
  • MF: C19H14F3N3O3
  • MW: 389.328
  • Catalog:Androgen Receptor Conditioner
  • Density: 1.4±0.1 g/cm3
  • Boiling Point: 632.3±55.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 336.2±31.5 °C
  • CAS Number: 10592-13-9
  • MF: C22H25ClN2O8
  • MW: 480.896
  • Catalog:MMP inhibitor
  • Density: 1.63 g/cm3
  • Boiling Point: 762.6ºC at 760 mmHg
  • Melting Point: 195-201℃
  • Flash Point: 415ºC
  • CAS Number: 443797-96-4
  • MF: C15H12F2N6O3S
  • MW: 394.356
  • Catalog:CDK inhibitor
  • Density: 1.7±0.1 g/cm3
  • Boiling Point: 676.6±65.0 °C at 760 mmHg
  • Melting Point: 149-155ºC
  • Flash Point: 363.0±34.3 °C
  • CAS Number: 844442-38-2
  • MF: C16H17Cl2N5O2
  • MW: 382.245
  • Catalog:CDK inhibitor
  • Density: 1.5±0.1 g/cm3
  • Boiling Point: 586.0±50.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 308.2±30.1 °C
  • CAS Number: 1374828-69-9
  • MF: C14H16F3N7
  • MW: 339.319
  • Catalog:LRRK2 inhibitor
  • Density: 1.4±0.1 g/cm3
  • Boiling Point: 506.3±60.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 260.0±32.9 °C
  • CAS Number: 518303-20-3
  • MF: C18H14BrNO5S2
  • MW: 468.341
  • Catalog:Bcl-2 inhibitor
  • Density: 1.79±0.1 g/cm3
  • Boiling Point: 661.2±65.0 °C at 760 mmHg
  • Melting Point: N/A
  • Flash Point: 353.7±34.3 °C
  • CAS Number: 172889-26-8
  • MF: C16H19N5
  • MW: 281.356
  • Catalog:Src inhibitor
  • Density: 1.2±0.1 g/cm3
  • Boiling Point: 478.8±40.0 °C at 760 mmHg
  • Melting Point: 205-207ºC
  • Flash Point: 243.4±27.3 °C