535974-91-5

535974-91-5 structure

Name: 5'-Iodoresiniferatoxin
Chemical Name: i-rtx
CAS Number: 535974-91-5
Molecular Formula: C₃₇H₃₉IO₉
Molecular Weight: 754.60
Catalog: Signaling Pathways Membrane Transporter/Ion Channel TRP Channel
Create Date: 2017-04-03 22:35:36
Modify Date: 2024-01-06 19:07:35
5-Iodoresiniferatoxin (I-RTX) is a selective TRPV1 antagonist, with an IC50s of 0.7 and 5.4 nM for rat and human receptors, respectively. 5-Iodoresiniferatoxin induces TRPV1-dependent hypothermia in vivo[1].

Name	i-rtx
Synonyms	[(1R,2R,6R,10S,11R,15R,17R)-13-Benzyl-6-hydroxy-15-isopropenyl-4,17-dimethyl-5-oxo-12,14,18-trioxapentacyclo[11.4.1.0.0.0]octadeca-3,8-dien-8-yl]methyl (4-hydroxy-3-iodo-5-methoxyphe nyl)acetate 5-I-RTX 5'-Iodoresiniferatoxin Benzeneacetic acid, 4-hydroxy-3-iodo-5-methoxy-, [(3aR,3bS,6aR,9aR,9bR,10R,11aR)-3a,3b,6,6a,9a,10,11,11a-octahydro-6a-hydroxy-8,10-dimethyl-11a-(1-methylethenyl)-7-oxo-2-(phenylmethyl)-7H-2,9b-epoxyazuleno[4',5':5,6]benzo[1,2-d]-1,3-dioxol-5-yl]methyl ester [(1R,2R,6R,10S,11R,15R,17R)-13-Benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-(prop-1-en-2-yl)-12,14,18-trioxapentacyclo[11.4.1.0.0.0]octadeca-3,8-dien-8-yl]methyl (4-hydroxy-3-iodo-5-methoxyphenyl)acetate

Description	5-Iodoresiniferatoxin (I-RTX) is a selective TRPV1 antagonist, with an IC50s of 0.7 and 5.4 nM for rat and human receptors, respectively. 5-Iodoresiniferatoxin induces TRPV1-dependent hypothermia in vivo[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Neurological Disease
Target	rTRPV1:0.7 nM (IC50) hTRPV1:5.4 nM (IC50)
References	[1]. Seabrook GR, et, al. Functional properties of the high-affinity TRPV1 (VR1) vanilloid receptor antagonist (4-hydroxy-5-iodo-3-methoxyphenylacetate ester) iodo-resiniferatoxin. J Pharmacol Exp Ther. 2002 Dec;303(3):1052-60. [2]. Shimizu I, et, al. 5-Iodoresiniferatoxin evokes hypothermia in mice and is a partial transient receptor potential vanilloid 1 agonist in vitro. J Pharmacol Exp Ther. 2005 Sep;314(3):1378-85.