5'-Iodoresiniferatoxin
Modify Date: 2026-07-05 19:13:07
5'-Iodoresiniferatoxin structure
|
Common Name | 5'-Iodoresiniferatoxin | ||
|---|---|---|---|---|
| CAS Number | 535974-91-5 | Molecular Weight | 754.60 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 782.4±60.0 °C at 760 mmHg | |
| Molecular Formula | C37H39IO9 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 427.0±32.9 °C | |
Use of 5'-Iodoresiniferatoxin5-Iodoresiniferatoxin (I-RTX) is a selective TRPV1 antagonist, with an IC50s of 0.7 and 5.4 nM for rat and human receptors, respectively. 5-Iodoresiniferatoxin induces TRPV1-dependent hypothermia in vivo[1]. |
| Name | i-rtx |
|---|---|
| Synonym | More Synonyms |
| Description | 5-Iodoresiniferatoxin (I-RTX) is a selective TRPV1 antagonist, with an IC50s of 0.7 and 5.4 nM for rat and human receptors, respectively. 5-Iodoresiniferatoxin induces TRPV1-dependent hypothermia in vivo[1]. |
|---|---|
| Related Catalog | |
| Target |
rTRPV1:0.7 nM (IC50) hTRPV1:5.4 nM (IC50) |
| References |
| Density | 1.6±0.1 g/cm3 |
|---|---|
| Boiling Point | 782.4±60.0 °C at 760 mmHg |
| Molecular Formula | C37H39IO9 |
| Molecular Weight | 754.60 |
| Flash Point | 427.0±32.9 °C |
| Exact Mass | 754.163879 |
| PSA | 120.75000 |
| LogP | 6.65 |
| Vapour Pressure | 0.0±2.8 mmHg at 25°C |
| Index of Refraction | 1.671 |
| InChIKey | TZUJORCXGLGWDV-OXSIMREDSA-N |
| SMILES | C=C(C)C12CC(C)C34OC(Cc5ccccc5)(OC1C3C=C(COC(=O)Cc1cc(I)c(O)c(OC)c1)CC1(O)C(=O)C(C)=CC14)O2 |
|
Name: Displacement of [3H]RTX from human TRPV1 expressed in CHO cells
Source: ChEMBL
Target: Transient receptor potential cation channel subfamily V member 1
External Id: CHEMBL2428534
|
|
Name: Agonist activity at human TRPV1 expressed in CHO cells assessed as stimulation of Ca2...
Source: ChEMBL
Target: Transient receptor potential cation channel subfamily V member 1
External Id: CHEMBL2428533
|
|
Name: Agonist activity at rat TRPV1 receptor expressed in CHO cells assessed as calcium 45 ...
Source: ChEMBL
Target: Transient receptor potential cation channel subfamily V member 1
External Id: CHEMBL926239
|
|
Name: Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of R...
Source: ChEMBL
Target: Transient receptor potential cation channel subfamily V member 1
External Id: CHEMBL3102685
|
|
Name: Agonist activity at human TRPV1 expressed in CHO cells assessed as 45Ca2+ uptake afte...
Source: ChEMBL
Target: Transient receptor potential cation channel subfamily V member 1
External Id: CHEMBL3102686
|
|
Name: Displacement of [3H]RTX from human TRPV1 expressed in CHO cells after 60 mins by liqu...
Source: ChEMBL
Target: Transient receptor potential cation channel subfamily V member 1
External Id: CHEMBL3100277
|
|
Name: Antagonist activity at human TRPV1 expressed in CHO cells assessed as inhibition of c...
Source: ChEMBL
Target: Transient receptor potential cation channel subfamily V member 1
External Id: CHEMBL2428531
|
|
Name: Human TRPV1 (Transient Receptor Potential channels)
Source: IUPHAR-DB
Target: TRPV1 (Transient Receptor Potential channels) [Homo sapiens]
External Id: 507_Human
|
|
Name: Inhibition of rat brain FAAH assessed by measuring [14C]anandamide hydrolysis at 50 u...
Source: ChEMBL
Target: Fatty-acid amide hydrolase 1
External Id: CHEMBL902592
|
Total 9, Current Page 1 of 1
1
| [(1R,2R,6R,10S,11R,15R,17R)-13-Benzyl-6-hydroxy-15-isopropenyl-4,17-dimethyl-5-oxo-12,14,18-trioxapentacyclo[11.4.1.0.0.0]octadeca-3,8-dien-8-yl]methyl (4-hydroxy-3-iodo-5-methoxyphe nyl)acetate |
| 5-I-RTX |
| 5'-Iodoresiniferatoxin |
| Benzeneacetic acid, 4-hydroxy-3-iodo-5-methoxy-, [(3aR,3bS,6aR,9aR,9bR,10R,11aR)-3a,3b,6,6a,9a,10,11,11a-octahydro-6a-hydroxy-8,10-dimethyl-11a-(1-methylethenyl)-7-oxo-2-(phenylmethyl)-7H-2,9b-epoxyazuleno[4',5':5,6]benzo[1,2-d]-1,3-dioxol-5-yl]methyl ester |
| [(1R,2R,6R,10S,11R,15R,17R)-13-Benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-(prop-1-en-2-yl)-12,14,18-trioxapentacyclo[11.4.1.0.0.0]octadeca-3,8-dien-8-yl]methyl (4-hydroxy-3-iodo-5-methoxyphenyl)acetate |