5'-Iodoresiniferatoxin

Modify Date: 2024-01-06 19:07:35

5'-Iodoresiniferatoxin structure	Common Name	5'-Iodoresiniferatoxin
	CAS Number	535974-91-5	Molecular Weight	754.60
	Density	1.6±0.1 g/cm3	Boiling Point	782.4±60.0 °C at 760 mmHg
	Molecular Formula	C₃₇H₃₉IO₉	Melting Point	N/A
	MSDS	N/A	Flash Point	427.0±32.9 °C

Use of 5'-Iodoresiniferatoxin

5-Iodoresiniferatoxin (I-RTX) is a selective TRPV1 antagonist, with an IC50s of 0.7 and 5.4 nM for rat and human receptors, respectively. 5-Iodoresiniferatoxin induces TRPV1-dependent hypothermia in vivo[1].

Name	i-rtx
Synonym	More Synonyms

Description	5-Iodoresiniferatoxin (I-RTX) is a selective TRPV1 antagonist, with an IC50s of 0.7 and 5.4 nM for rat and human receptors, respectively. 5-Iodoresiniferatoxin induces TRPV1-dependent hypothermia in vivo[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Neurological Disease
Target	rTRPV1:0.7 nM (IC50) hTRPV1:5.4 nM (IC50)
References	[1]. Seabrook GR, et, al. Functional properties of the high-affinity TRPV1 (VR1) vanilloid receptor antagonist (4-hydroxy-5-iodo-3-methoxyphenylacetate ester) iodo-resiniferatoxin. J Pharmacol Exp Ther. 2002 Dec;303(3):1052-60. [2]. Shimizu I, et, al. 5-Iodoresiniferatoxin evokes hypothermia in mice and is a partial transient receptor potential vanilloid 1 agonist in vitro. J Pharmacol Exp Ther. 2005 Sep;314(3):1378-85.

Density	1.6±0.1 g/cm3
Boiling Point	782.4±60.0 °C at 760 mmHg
Molecular Formula	C₃₇H₃₉IO₉
Molecular Weight	754.60
Flash Point	427.0±32.9 °C
Exact Mass	754.163879
PSA	120.75000
LogP	6.65
Vapour Pressure	0.0±2.8 mmHg at 25°C
Index of Refraction	1.671

[(1R,2R,6R,10S,11R,15R,17R)-13-Benzyl-6-hydroxy-15-isopropenyl-4,17-dimethyl-5-oxo-12,14,18-trioxapentacyclo[11.4.1.0.0.0]octadeca-3,8-dien-8-yl]methyl (4-hydroxy-3-iodo-5-methoxyphe nyl)acetate

5-I-RTX

5'-Iodoresiniferatoxin

Benzeneacetic acid, 4-hydroxy-3-iodo-5-methoxy-, [(3aR,3bS,6aR,9aR,9bR,10R,11aR)-3a,3b,6,6a,9a,10,11,11a-octahydro-6a-hydroxy-8,10-dimethyl-11a-(1-methylethenyl)-7-oxo-2-(phenylmethyl)-7H-2,9b-epoxyazuleno[4',5':5,6]benzo[1,2-d]-1,3-dioxol-5-yl]methyl ester

[(1R,2R,6R,10S,11R,15R,17R)-13-Benzyl-6-hydroxy-4,17-dimethyl-5-oxo-15-(prop-1-en-2-yl)-12,14,18-trioxapentacyclo[11.4.1.0.0.0]octadeca-3,8-dien-8-yl]methyl (4-hydroxy-3-iodo-5-methoxyphenyl)acetate

5'-Iodoresiniferatoxin

Use of 5'-Iodoresiniferatoxin

Names

5'-Iodoresiniferatoxin Biological Activity

Chemical & Physical Properties

Synonyms