543700-68-1

543700-68-1 structure

Name: BMS433771
Chemical Name: 1-cyclopropyl-3-[[1-(4-hydroxybutyl)benzimidazol-2-yl]methyl]imidazo[4,5-c]pyridin-2-one
CAS Number: 543700-68-1
Molecular Formula: C₂₁H₂₃N₅O₂
Molecular Weight: 377.44000
Catalog: Signaling Pathways Anti-infection RSV
Create Date: 2017-01-30 01:16:14
Modify Date: 2024-01-04 20:34:55
BMS-433771 is a potent orally active inhibitor of respiratory syncytial virus (RSV). BMS-433771 is active against both A and B groups of RSV, with an average EC50 of 20 nM. BMS-433771 can be used for the research of respiratory tract disease[1][2].

Name	1-cyclopropyl-3-[[1-(4-hydroxybutyl)benzimidazol-2-yl]methyl]imidazo[4,5-c]pyridin-2-one
Synonyms	BMS433771

Description	BMS-433771 is a potent orally active inhibitor of respiratory syncytial virus (RSV). BMS-433771 is active against both A and B groups of RSV, with an average EC50 of 20 nM. BMS-433771 can be used for the research of respiratory tract disease[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> RSV
Target	EC50: 20 nM (RSV)[1]
In Vitro	BMS-433771 has inhibitory against both A and B groups of RSV, with an average EC50 of 20 nM[1]. BMS-433771 can inhibit viral F protein-induced membrane fusion[1].
In Vivo	BMS-433771 (p.o.; 1-200 mg/kg; single or bid 4 days) shows prophylactic efficacy via oral dosing，but has considerable pharmacodynamic differences between the two rodent models[2] . Animal Model: rodent models of RSV infection[2] (cotton rat and mice) Dosage: 1, 10, and 50 mg/kg (mice); 25, 50, 100, and 200 mg/kg (rat) Administration: oral, single or bid 4 days Result: Had prophylactic efficacy via oral dosing in both animal models. Showed RSV infection more sensitive to inhibition in the BALB/c mouse host than in the cotton rat.