BMS433771
Modify Date: 2024-01-04 20:34:55
BMS433771 structure
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Common Name | BMS433771 | ||
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| CAS Number | 543700-68-1 | Molecular Weight | 377.44000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H23N5O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BMS433771BMS-433771 is a potent orally active inhibitor of respiratory syncytial virus (RSV). BMS-433771 is active against both A and B groups of RSV, with an average EC50 of 20 nM. BMS-433771 can be used for the research of respiratory tract disease[1][2]. |
| Name | 1-cyclopropyl-3-[[1-(4-hydroxybutyl)benzimidazol-2-yl]methyl]imidazo[4,5-c]pyridin-2-one |
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| Synonym | More Synonyms |
| Description | BMS-433771 is a potent orally active inhibitor of respiratory syncytial virus (RSV). BMS-433771 is active against both A and B groups of RSV, with an average EC50 of 20 nM. BMS-433771 can be used for the research of respiratory tract disease[1][2]. |
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| Related Catalog | |
| Target |
EC50: 20 nM (RSV)[1] |
| In Vitro | BMS-433771 has inhibitory against both A and B groups of RSV, with an average EC50 of 20 nM[1]. BMS-433771 can inhibit viral F protein-induced membrane fusion[1]. |
| In Vivo | BMS-433771 (p.o.; 1-200 mg/kg; single or bid 4 days) shows prophylactic efficacy via oral dosing，but has considerable pharmacodynamic differences between the two rodent models[2] . Animal Model: rodent models of RSV infection[2] (cotton rat and mice) Dosage: 1, 10, and 50 mg/kg (mice); 25, 50, 100, and 200 mg/kg (rat) Administration: oral, single or bid 4 days Result: Had prophylactic efficacy via oral dosing in both animal models. Showed RSV infection more sensitive to inhibition in the BALB/c mouse host than in the cotton rat. |
| Molecular Formula | C21H23N5O2 |
|---|---|
| Molecular Weight | 377.44000 |
| Exact Mass | 377.18500 |
| PSA | 77.87000 |
| LogP | 2.70340 |
| BMS433771 |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: BMS-433771
- Price: Negotiable
- Purity: 99.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: BMS433771
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- DC Chemicals Limited
- China
- Product Name: BMS433771
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
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