76-78-8
76-78-8 structure
- Name: Quassin
- Chemical Name: quassin
- CAS Number: 76-78-8
- Molecular Formula: C22H28O6
- Molecular Weight: 388.454
- Catalog: Organic raw materials Amino compound Sulfonic acid amino compound
- Create Date: 2018-09-22 12:41:16
- Modify Date: 2026-07-08 17:52:32
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Quassin (Nigakilactone D) is a bioactive triterpenoid from stem bark extract of Quassia amara. Quassin inhibits P. falciparum with an IC50 of 0.15 μM. Quassin possesses reversible antifertility, anti-estrogenic and anti-plasmodial activity[1][2].
| Name | quassin |
|---|---|
| Synonyms |
Quassin, mixture of isomers w/Neoquassin and Isoquassin
(3aS,6,7aS,8S,11aS,11bS,11cS)-1,3a,4,5,6a,7,7a,8,11,11a,11b,11c-dodecahydro-2,10-dimethoxy-3,8,11a Quassin (Mixture of Quassin, Isoquassin and Neoquassin) Quassin,mixture of isomers w/Neoquassin and Isoquassin Picrasa-2,12-diene-1,11,16-trione,2,12-dimethoxy 3ab,6ab,7,7aa,8,11a,11ba,11c-Octahydro-2,10-dimethoxy-3,8a,11ab,11cb-tetramethylphenanthro[10,1-bc]pyran-1,5,11(4H)-trione Picrasa-2,12-diene-1,11,16-trione, 2,12-dimethoxy Quassin - isomeric mixture of isoquassin, neoquassin and quassin 4-iquassin Alloquassin (3As,6,7as,8S,11as,11bs,11cs)-1,3A,4,5,6A,7,7A,8,11,11A,11B,11C-dodecahydro-2,10-dimethoxy-3,8,11A,11C-tetramethyldibenzo(de,G)chromene-1,5,11-trione Nsc Einecs 200-985-9 Anti-infection Quassin (~) PYROGALLIC ACID (RG) Quassin (> (3aR,6aR,7aS,8S,11aS,11bS,11cS)-2,10-Dimethoxy-3,8,11a,11c-tetramethyl-3a,6a,7,7a,8,11a,11b,11c-octahydrodibenzo[de,g]chromene-1,5,11(4H)-trione Reaxys ID 2,12-Dimethoxypicrasa-2,12-diene-1,11,16-trione QUASSINPOWDER 11,16-trione,2,12-dimethoxy-picrasa-12-diene-1 Nigakilactone D Balsam Einecs -9 QUASSIN Quassin-RM |
| Description | Quassin (Nigakilactone D) is a bioactive triterpenoid from stem bark extract of Quassia amara. Quassin inhibits P. falciparum with an IC50 of 0.15 μM. Quassin possesses reversible antifertility, anti-estrogenic and anti-plasmodial activity[1][2]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 0.15 μM (P. falciparum)[2] |
| In Vitro | Quassin (Compound 1; 5-25 ng/mL) inhibits both the basal and luteinizing hormone-stimulated testosterone secretion of rat Leydig cells in a dose-dependent fashion[3]. |
| In Vivo | Quassin (0.1-2.0 mg/kg; oral administration; daily; for 60 days; females albino rats) treatment shows a significant decrease in the weight of the ovary and uterus. And also shows a significant decrease in serum estrogen levels in quassin treated rats. The Quassin treated rats has a significantly decreased mean litter number and weight. Quassin does not adversely affect the weight of the kidney, heart, liver and the body of the rats[1]. Animal Model: 35 females albino rats (150-170 g)[1] Dosage: 0.1 mg/kg, 1.0 mg/kg and 2.0 mg/kg Administration: Oral administration; daily; for 60 days Result: There was a significant decrease in the weight of the ovary and uterus in all the groups relative to the control. There was also a significant decrease in serum estrogen levels in quassin treated rats. |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 586.3±50.0 °C at 760 mmHg |
| Melting Point | 200 - 222ºC |
| Molecular Formula | C22H28O6 |
| Molecular Weight | 388.454 |
| Flash Point | 255.4±30.2 °C |
| Exact Mass | 388.188599 |
| PSA | 78.90000 |
| LogP | 2.22 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.553 |
| Storage condition | 2-8℃ |
| Hazard Codes | Xi |
|---|
| Precursor 0 | |
|---|---|
| DownStream 2 | |
