139893-43-9
139893-43-9 structure
- Name: Simvastatin ammonium salt
- Chemical Name: Simvastatin Ammonium Salt
- CAS Number: 139893-43-9
- Molecular Formula: C25H43NO6
- Molecular Weight: 453.612
- Catalog: Research Areas Cardiovascular Disease
- Create Date: 2018-03-29 08:00:00
- Modify Date: 2026-07-08 11:22:30
-
Simvastatin ammonium is an active metabolite of simvastatin lactone mediated by CYP3A4/5 in the intestinal wall and liver (pKa=5.5). Simvastatin ammonium reduces indoxyl sulfate-mediated reactive oxygen species and modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene[1].
| Name | Simvastatin Ammonium Salt |
|---|---|
| Synonyms |
1-Naphthalenehtanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-b,d-dihydroxy-2,6-dimethyl-, monoammonium salt,(bR,dR,1S,2S,6R,8S,8)- (9CI)
Simvastatin hydroxyl acid ammonium salt Simvastatin ammonium saltr Simvastatin Impurity(Ammonium Salt) 1-Naphthalenehtanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-, ammonium salt (1:1), (βR,δR,1S,2S,6R,8S,8) Simvastatin cboxylic acid ammonium salt Simvastatin acid ammonium Simvastatin Impurity 1 Ammonium Salt(Simvastatin Impurity A Ammonium Salt) (3R,5R)-7-((1S,2S,6R,8S,8-8-(2,2-dimethylbutanoyloxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)-3,5-dihydroxyhtanoate ammonium salt SIMV-IM B D6-Simvastatin Hydroxy Acid Ammonium Salt (βR,δR,1S,2S,6R,8S,8-8-(2,2-Dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-1-naphthalenehtanoic acid ammonium salt Ammonium (3R,5R)-7-{(1S,2S,6R,8S,8aR)-8-[(2,2-dimethylbutanoyl)oxy]-2,6-dimethyl-1,2,6,7,8,8a-hexahydro-1-naphthalenyl}-3,5-dihydroxyheptanoate Simvastatin carboxylic acid ammonium salt Simvastatin Impurity A as Ammonium Salt (3R,5R)-7-[(1S,2S,6R,8S,8-8-[(2,2-Dimethylbutanoyl)oxy]-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyhtanoic Acid Ammonium Salt (Tenivastatin Ammonium Salt) IMVASTATIN AMMOUNIUM SALT 1-Naphthaleneheptanoate, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-β,δ-dihydroxy-2,6-dimethyl-, ammonium salt, (βR,δR,1S,2S,6R,8S,8aR)- (1:1) SIMVASTATIN AMMOUNIUM SALT Impurity A (simvastatin hydroxy acid) Simvastatin Impurity 1 SIMVASTATIN HYDROXY ACID, AMMONIUM SALT Simvastatin impurity A SIMVASTATIN AMMONIUM SALT Simvastatin hydroxy acid ammonium salt Simvastatin hydroxy acid D6 ammonium saltQ: What is Simvastatin hydroxy acid D6 ammonium salt Q: What is the CAS Number of Simvastatin hydroxy acid D6 ammonium salt Q: What is the storage condition of Simvastatin hydroxy acid D6 ammonium salt Q: What e the applications of Simvastatin hydroxy acid D6 ammonium salt 1-Naphthalenehtanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a-hexahydro-,d-dihydroxy-2,6-dimethyl-, monoammonium salt, (R,dR,1S,2S,6R,8S,8)- (9CI) Ammonium (3R,5R)-7-[(1S,2S,6R,8S,8-8-(2,2-dimethylbutyryloxy)-1,2,6,7,8,8a-hexahydro-2,6-dimethyl-1-naphthyl]-3,5-dihydroxyhtanoate Simvastatin Ammonium Salt (SAS) (βR,δR,1S,2S,6R,8S,8) Simvastatin Acid Ammonium Salt(Simvastatin Ammonium) Tenivastatin ammonium salt azanium,(3R,5R)-7-[(1S,2S,6R,8S,8aR)-8-(2,2-dimethylbutanoyloxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoate ammonium (3R,5R)-7-((1S,2S,6R,8S,8-8-(2,2-dimethylbutanoyloxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)-3,5-dihydroxyhtanoate (3S,5S)-7-((1R,2R,6S,8R,8aS)-8-((2,2-dimethylbutanoyl)oxy)-2,6-dimethyl-1,2,6,7,8,8a-hexahydronaphthalen-1-yl)-3,5-dihydroxyhtanoic acid, ammonia salt Simvastatin acid ammonium salt Simvastatin hydroxy acid ammonium salt, >= Simvastatin hydroxy acid D3 ammonium saltQ: What is Simvastatin hydroxy acid D3 ammonium salt Q: What is the CAS Number of Simvastatin hydroxy acid D3 ammonium salt Q: What is the storage condition of Simvastatin hydroxy acid D3 ammonium salt 1-Naphthalenehtanoic acid, 8-(2,2-dimethyl-1-oxobutoxy)-1,2,6,7,8,8a Simvastatin Hydroxy Acid Ammonium SaltQ: What is Simvastatin Hydroxy Acid Ammonium Salt Q: What is the CAS Number of Simvastatin Hydroxy Acid Ammonium Salt Q: What is the storage condition of Simvastatin Hydroxy Acid Ammonium Salt Q: What e the applications of Simvastatin Hydroxy Acid Ammonium Salt |
| Description | Simvastatin ammonium is an active metabolite of simvastatin lactone mediated by CYP3A4/5 in the intestinal wall and liver (pKa=5.5). Simvastatin ammonium reduces indoxyl sulfate-mediated reactive oxygen species and modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene[1]. |
|---|---|
| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| In Vitro | There is a pH-dependent effect on organic anion transporting polypeptide 3A1 (OATP3A1) uptake, with more efficient simvastatin acid uptake at pH5.5 in HEK293 cells transfected with the OATP3A1 gene. The Michaelis-Menten constant (Km) for simvastatin acid uptake by OATP3A1 was 0.017 μM and the Vmax was 0.995 fmol/min/105 cells[1]. |
| References |
| Molecular Formula | C25H43NO6 |
|---|---|
| Molecular Weight | 453.612 |
| Exact Mass | 453.309052 |
| PSA | 107.30000 |
| LogP | 4.42960 |
| Symbol |
GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H351-H360-H412 |
| Precautionary Statements | P201-P273-P281-P308 + P313 |
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | 26-36 |
| RIDADR | NONH for all modes of transport |