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5330-29-0

5330-29-0 structure
5330-29-0 structure

Name 8-(6-diethylaminohexylamino)-6-methoxy-4-methylquinoline, dihydrochloride
Synonyms N,N-Diethyl-N'-(6-methoxy-4-methyl-8-quinolinyl)-1,6-hexanediamine,Dihydrochloride
6-methoxy-8-(diethylaminohexylamino)lepidine dihydrochloride
sitamaquine dihydrochloride
N,N-diethyl-N'-(6-methoxy-4-methyl-8-quinolyl)hexane-1,6-diamine dihydrochloride
6-methoxy-8-(6-diethylaminohexylamino)lepidine dihydrochloride
8-(6-diethylaminohexylamino)-6-methoxy-4-methylquinoline dihydrochloride
Boiling Point 502.8ºC at 760mmHg
Molecular Formula C21H34ClN3O
Molecular Weight 379.96700
Flash Point 257.9ºC
Exact Mass 379.23900
PSA 37.39000
LogP 5.74090

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MO1294500
CHEMICAL NAME :
1,6-Hexanediamine, N,N-diethyl-N(sup 1)-(6-methoxy-4-methyl-8-quinolinyl)-, dihydrochloride
CAS REGISTRY NUMBER :
5330-29-0
LAST UPDATED :
199801
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C21-H33-N3-O.2Cl-H
MOLECULAR WEIGHT :
416.49

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1252 mg/kg/13W-I
TOXIC EFFECTS :
Endocrine - changes in spleen weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
REFERENCE :
DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 40,75,1997
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
313 mg/kg/13W-I
TOXIC EFFECTS :
Endocrine - changes in spleen weight Nutritional and Gross Metabolic - weight loss or decreased weight gain Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - transaminases
REFERENCE :
DDREDK Drug Development Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1981- Volume(issue)/page/year: 40,75,1997 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
480 mg/kg
SEX/DURATION :
female 6-15 day(s) after conception
TOXIC EFFECTS :
Reproductive - Maternal Effects - other effects
REFERENCE :
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981- Volume(issue)/page/year: 3,65,1983