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99291-25-5

99291-25-5 structure
99291-25-5 structure
  • Name: Levodropropizine
  • Chemical Name: levodropropizine
  • CAS Number: 99291-25-5
  • Molecular Formula: C13H20N2O2
  • Molecular Weight: 236.310
  • Catalog: Pharmaceutical intermediate Heterocyclic compound Piperazine
  • Create Date: 2018-02-21 08:00:00
  • Modify Date: 2025-08-21 12:29:58
  • Levodropropizine (DF-526) is a histamine receptor inhibitor, Levodropropizine is an effective and very well tolerated peripheral antitussive drug.
Name levodropropizine
Synonyms (S)-dropropizine
Levdropropizina
1,2-Propanediol,3-(4-phenyl-1-piperazinyl)-,(R)
(-)-Dropropizine
rapitux
1,2-Propanediol, 3-(4-phenyl-1-piperazinyl)-, (2S)-
(+)-Dropropizine
(2S)-3-(4-phenylpiperazin-1-yl)propane-1,2-diol
(R)-3-(4-Phenylpiperazin-1-yl)propane-1,2-diol
Levdropropizina [Latin,Spanish]
(2S)-3-(4-Phenyl-1-piperazinyl)-1,2-propanediol
(R)-3-(4-Phenyl-1-piperazinyl)-1,2-propanediol
Levodropropizine
Dropropizine S-form
Density 1.2±0.1 g/cm3
Boiling Point 412.7±34.0 °C at 760 mmHg
Melting Point 102-106ºC
Molecular Formula C13H20N2O2
Molecular Weight 236.310
Flash Point 220.9±24.3 °C
Exact Mass 236.152481
PSA 46.94000
LogP 0.46
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.577
Storage condition Refrigerator

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TZ1075100
CHEMICAL NAME :
1,2-Propanediol, 3-(4-phenylpiperazin-1-yl)-, S(-)-
CAS REGISTRY NUMBER :
99291-25-5
LAST UPDATED :
199609
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C13-H20-N2-O2
MOLECULAR WEIGHT :
236.35

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
887 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 38,1150,1988
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
401 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 38,1150,1988
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1281 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Gastrointestinal - other changes
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 38,1150,1988
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
408 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 38,1150,1988
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
2493 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Gastrointestinal - other changes
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 38,1150,1988
HS Code 2933599090
92-54-6 structure

92-54-6

~%

99291-25-5 structure

99291-25-5

Literature: US4699911 A1, ;
92-54-6 structure

92-54-6

50765-70-3 structure

50765-70-3

~47%

99291-25-5 structure

99291-25-5

Literature: Giani; Marinone; Melillo; Borsa; Tonon Arzneimittel-Forschung/Drug Research, 1988 , vol. 38, # 8 p. 1139 - 1141
92-54-6 structure

92-54-6

70987-78-9 structure

70987-78-9

~%

99291-25-5 structure

99291-25-5

Literature: Arzneimittel-Forschung/Drug Research, , vol. 38, # 8 p. 1139 - 1141
Precursor  3

DownStream  0

HS Code 2933599090
Summary 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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