96737-93-8

96737-93-8 structure

Name: 5β-Pregnan-3α-ol-20-one-17α,21,21,21-d4
Chemical Name: Pregnan-20-one-17,21,21,21-d4, 3-hydroxy-, (3α,5β)-
CAS Number: 96737-93-8
Molecular Formula: C₂₁H₃₄O₂
Molecular Weight: 318.49300
Create Date: 2017-02-21 14:45:27
Modify Date: 2024-01-02 12:07:12
5β-Pregnan-3α-ol-20-one-17α,21,21,21-d4 is the deuterium labeled Pregnanolone. Pregnanolone (Eltanolone), a Progesterone metabolite, is a neurosteroid. Pregnanolone is a GABAA receptor positive allosteric modulator. Pregnanolone has anxiolytic and antidepressant effects[1].

Name	Pregnan-20-one-17,21,21,21-d4, 3-hydroxy-, (3α,5β)-
Synonyms	5β-PREGNAN-3α-OL-20-ONE-17α,21,21,21-D4

Description	5β-Pregnan-3α-ol-20-one-17α,21,21,21-d4 is the deuterium labeled Pregnanolone. Pregnanolone (Eltanolone), a Progesterone metabolite, is a neurosteroid. Pregnanolone is a GABAA receptor positive allosteric modulator. Pregnanolone has anxiolytic and antidepressant effects[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Tereza Smejkalova, et al. Endogenous neurosteroids pregnanolone and pregnanolone sulfate potentiate presynaptic glutamate release through distinct mechanisms. Br J Pharmacol. 2021 Oct;178(19):3888-3904.