827044-38-2

827044-38-2 structure

Name: Abz-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH
Chemical Name: Abz-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH
CAS Number: 827044-38-2
Molecular Formula: C₄₁H₆₁N₁₃O₁₂
Molecular Weight: 928.00
Catalog: Research Areas Others
Create Date: 2017-08-21 22:10:36
Modify Date: 2024-01-09 13:02:36
Abz-GIVRAK(Dnp) is the most efficient substrate for cathepsin B and is highly selective for this enzyme among lysosomal cysteine proteases. After Abz-GIVRAK(Dnp) is hydrolyzed, aminoacylbenziminosulfosuccinic acid (Abz-SAS) is released, and dinitrobenzoyl (Dnp) is also released. The product of this hydrolysis reaction, Abz-SAS, is fluorescent under ultraviolet light and can emit a fluorescent signal[1].

Name	Abz-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH

Description	Abz-GIVRAK(Dnp) is the most efficient substrate for cathepsin B and is highly selective for this enzyme among lysosomal cysteine proteases. After Abz-GIVRAK(Dnp) is hydrolyzed, aminoacylbenziminosulfosuccinic acid (Abz-SAS) is released, and dinitrobenzoyl (Dnp) is also released. The product of this hydrolysis reaction, Abz-SAS, is fluorescent under ultraviolet light and can emit a fluorescent signal[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Cotrin SS, et, al. Positional-scanning combinatorial libraries of fluorescence resonance energy transfer peptides to define substrate specificity of carboxydipeptidases: assays with human cathepsin B. Anal Biochem. 2004 Dec 15;335(2):244-52.