141663-86-7

141663-86-7 structure

Name: Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2
Chemical Name: Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2
CAS Number: 141663-86-7
Molecular Formula: C₄₇H₆₅N₉O₉
Molecular Weight: 900.07400
Catalog: Signaling Pathways GPCR/G Protein Neurokinin Receptor
Create Date: 2019-02-05 10:00:54
Modify Date: 2024-01-12 10:17:00
GR 87389 is a potent NK2 receptor antagonist. GR 87389 antagonized GA 64349-induced smooth muscle strips contractions in a competitive manner in the human detrusor, prostate and prostatic urethra[1][2].

Name	Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2
Synonyms	boc-ala-ala-d-trp-phe-d-pro-pro-nle-nh2

Description	GR 87389 is a potent NK2 receptor antagonist. GR 87389 antagonized GA 64349-induced smooth muscle strips contractions in a competitive manner in the human detrusor, prostate and prostatic urethra[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor
Target	NK2
In Vitro	GR 87389 是一种非肽和肽速激肽拮抗剂，对海马、膀胱和十二指肠的 Ki 值分别为 4.0、5.2 和 14 nM[1]。 GR 87389 (30-300 nM) 拮抗 GA 64349 诱导的人类逼尿肌、前列腺和前列腺尿道平滑肌条收缩[2]。
References	[1]. Saffroy M, et, al. Presence of NK2 binding sites in the rat brain. J Neurochem. 2001 Dec;79(5):985-96. [2]. Palea S, et, al. Pharmacological characterization of tachykinin NK2 receptors on isolated human urinary bladder, prostatic urethra and prostate. J Pharmacol Exp Ther. 1996 May;277(2):700-5.