Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2

Modify Date: 2025-08-23 17:27:59

Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2 structure	Common Name	Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2
	CAS Number	141663-86-7	Molecular Weight	900.07400
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₄₇H₆₅N₉O₉	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2

GR 87389 is a potent NK2 receptor antagonist. GR 87389 antagonized GA 64349-induced smooth muscle strips contractions in a competitive manner in the human detrusor, prostate and prostatic urethra[1][2].

Name	Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2
Synonym	More Synonyms

Description	GR 87389 is a potent NK2 receptor antagonist. GR 87389 antagonized GA 64349-induced smooth muscle strips contractions in a competitive manner in the human detrusor, prostate and prostatic urethra[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor
Target	NK2
In Vitro	GR 87389 是一种非肽和肽速激肽拮抗剂，对海马、膀胱和十二指肠的 Ki 值分别为 4.0、5.2 和 14 nM[1]。 GR 87389 (30-300 nM) 拮抗 GA 64349 诱导的人类逼尿肌、前列腺和前列腺尿道平滑肌条收缩[2]。
References	[1]. Saffroy M, et, al. Presence of NK2 binding sites in the rat brain. J Neurochem. 2001 Dec;79(5):985-96. [2]. Palea S, et, al. Pharmacological characterization of tachykinin NK2 receptors on isolated human urinary bladder, prostatic urethra and prostate. J Pharmacol Exp Ther. 1996 May;277(2):700-5.

Molecular Formula	C₄₇H₆₅N₉O₉
Molecular Weight	900.07400
Exact Mass	899.49100
PSA	254.23000
LogP	5.01350
InChIKey	TULKQVVKMIIQFE-DWZVVYGRSA-N
SMILES	CCCCC(NC(=O)C1CCCN1C(=O)C1CCCN1C(=O)C(Cc1ccccc1)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(C)NC(=O)C(C)NC(=O)OC(C)(C)C)C(N)=O

Name: Compound was evaluated for antagonism of contractile response of guinea pig ileum lon...
Source: ChEMBL
Target: Substance-P receptor
External Id: CHEMBL810507

Name: Compound was evaluated for antagonism of contractile response of rat colon muscularis...
Source: ChEMBL
Target: Substance-K receptor
External Id: CHEMBL812069

Name: Compound was evaluated for antagonism of contractile response of rat portal vein at T...
Source: ChEMBL
Target: Neuromedin-K receptor
External Id: CHEMBL815578

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boc-ala-ala-d-trp-phe-d-pro-pro-nle-nh2

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Use of Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2

Names

Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2 Biological Activity

Chemical & Physical Properties

Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2Bioassay

Synonyms

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