Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2
Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2 structure
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Common Name | Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2 | ||
|---|---|---|---|---|
| CAS Number | 141663-86-7 | Molecular Weight | 900.07400 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C47H65N9O9 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2GR 87389 is a potent NK2 receptor antagonist. GR 87389 antagonized GA 64349-induced smooth muscle strips contractions in a competitive manner in the human detrusor, prostate and prostatic urethra[1][2]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2 |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | GR 87389 is a potent NK2 receptor antagonist. GR 87389 antagonized GA 64349-induced smooth muscle strips contractions in a competitive manner in the human detrusor, prostate and prostatic urethra[1][2]. |
|---|---|
| Related Catalog | |
| Target |
NK2 |
| In Vitro | GR 87389 是一种非肽和肽速激肽拮抗剂，对海马、膀胱和十二指肠的 Ki 值分别为 4.0、5.2 和 14 nM[1]。 GR 87389 (30-300 nM) 拮抗 GA 64349 诱导的人类逼尿肌、前列腺和前列腺尿道平滑肌条收缩[2]。 |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Molecular Formula | C47H65N9O9 |
|---|---|
| Molecular Weight | 900.07400 |
| Exact Mass | 899.49100 |
| PSA | 254.23000 |
| LogP | 5.01350 |
| InChIKey | TULKQVVKMIIQFE-DWZVVYGRSA-N |
| SMILES | CCCCC(NC(=O)C1CCCN1C(=O)C1CCCN1C(=O)C(Cc1ccccc1)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(C)NC(=O)C(C)NC(=O)OC(C)(C)C)C(N)=O |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Compound was evaluated for antagonism of contractile response of guinea pig ileum lon...
Source: ChEMBL
Target: Substance-P receptor
External Id: CHEMBL810507
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Name: Compound was evaluated for antagonism of contractile response of rat colon muscularis...
Source: ChEMBL
Target: Substance-K receptor
External Id: CHEMBL812069
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Name: Compound was evaluated for antagonism of contractile response of rat portal vein at T...
Source: ChEMBL
Target: Neuromedin-K receptor
External Id: CHEMBL815578
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| boc-ala-ala-d-trp-phe-d-pro-pro-nle-nh2 |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the Chinese name of 141663-86-7? |
| A: Chinese name of 141663-86-7 is BOC-ALA-ALA-D-TRP-PHE-D-PRO-PRO-NLE-NH2. |
| Q: What English synonyms does Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2 have? |
| A: English synonyms of Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2: boc-ala-ala-d-trp-phe-d-pro-pro-nle-nh2. |
| Q: What is the molecular formula of Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2? |
| A: Molecular formula of Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2 is C47H65N9O9. |
| Q: What is the SMILES notation of Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2? |
| A: SMILES notation of Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2 is CCCCC(NC(=O)C1CCCN1C(=O)C1CCCN1C(=O)C(Cc1ccccc1)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(C)NC(=O)C(C)NC(=O)OC(C)(C)C)C(N)=O. |
| Q: What is the polar surface area (PSA) of Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2? |
| A: Polar surface area (PSA) of Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2 is 254.23000. |
| Q: What is the InChIKey of Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2? |
| A: InChIKey of Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2 is TULKQVVKMIIQFE-DWZVVYGRSA-N. |
| Q: What is the English name of Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2? |
| A: The English name of Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2 is Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2. |
| Q: What is the CAS number of Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2? |
| A: CAS number of Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2 is 141663-86-7. |
| Q: What is the molecular weight of Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2? |
| A: Molecular weight of Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2 is 900.07400. |
| Q: What are the uses of Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2? |
| A: Main uses of Boc-Ala-Ala-D-Trp-Phe-D-Pro-Pro-NleNH2: GR 87389 is a potent NK2 receptor antagonist. GR 87389 antagonized GA 64349-induced smooth muscle strips contractions in a competitive manner in the human detrusor, prostate and prostatic urethra[1][2]. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Dayang Chem (Hangzhou) Co., Ltd. |