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63555-63-5

63555-63-5 structure
63555-63-5 structure
  • Name: C3a (70-77) trifluoroacetate salt
  • Chemical Name: C3a (70-77),ASHLGLAR
  • CAS Number: 63555-63-5
  • Molecular Formula: C35H61N13O10
  • Molecular Weight: 823.94000
  • Catalog: Peptides
  • Create Date: 2018-12-13 17:50:09
  • Modify Date: 2024-01-12 18:05:58
  • C3a (70-77) is an octapeptide corresponding to the COOH terminus of C3a, exhibits the specificity and 1 to 2% biologic activities of C3a.
Name C3a (70-77),ASHLGLAR
Synonyms ALA-SER-HIS-LEU-GLY-LEU-ALA-ARG
H-ALA-SER-HIS-LEU-GLY-LEU-ALA-ARG-OH
complement 3a (70-77)
alanine-serine-histidine-leucine-glycine-leucine-alanine
ANAPHYLATOXIN C3A FRAGMENT 70-77
ASHLGLAR
L-Alanyl-L-seryl-L-histidyl-L-leucyl-glycyl-L-leucyl-L-alanyl-L-arginine
C3A (70-77)
Description C3a (70-77) is an octapeptide corresponding to the COOH terminus of C3a, exhibits the specificity and 1 to 2% biologic activities of C3a.
Related Catalog
Target

Complement system[1]
In Vitro The direct interaction of C3a(70-77) with human mononuclear leukocytes in culture results in a concentrationdependent inhibition of the generation of LIF evoked by mitogens and by the antigen SK-SD. The extent of suppression of LIF generation by C3a(70-77) is significant at concentrations of 10-7 M or higher and exceeds 75% at 10-6 M, irrespective of the stimulus[1]. C3a (70-77), an octapeptide corresponding to the COOH terminus of human C3a, exhibits the specificity and biologic activities of C3a. Although lacking 69 residues at the NH2 terminus, it maintains 1 to 2% of the activity of natural human C3a. C3a (70-77), Ala-Ser-HisLeu-Gly-Leu-Ala-Arg, induces histamine release and degranulation of rat mast cells, promotes contraction of guinea pig ileal tissue, and enhances vascular permeability in human skin. C3a (70-77) selectively desensitizes ileal smooth muscle to C3a but not to human C5a, a related anaphylatoxin. Conversely, C3a-(70-77) is unable to contract ileal smooth muscle pretreated with natural C3a. This cross-desensitization indicates a specific interaction of C3a (70-77) with cellular C3a binding sites[2].
Kinase Assay 2×105 mononuelear leukocytes in 0.2 mL of M199-HPS containing 15% (vol/vol) AB-positive serum are added to each well of microtiter plates without or with 10 μg/mL of Con A, PHA, or SK-SD and incubated at 37°C in 5% CO2:95% air. C3a or C3a(70-77) is introduced into some suspensions at the same time as the stimulus or buffer. After 3 d for the mitogen-stimulated cultures and 5 d for the SK-SD-stimulated cultures, 1 μCi of [3H]thymidine is added to each well. After an additional 16 h at 37°C, the uptake of [3H]thymidine is analyzed by aspirating the contents of each well with a Mash II harvester that collected and ished the leukocytes on glass fiber filters. The radioactivity in each filter is quantified, and the results for quadruplicate chambers are expressed as mean cpm+SEM[1].
References

[1]. Payan DG, et al. Modulation of human lymphocyte function by C3a and C3a(70-77). J Exp Med. 1982 Sep 1;156(3):756-65.

[2]. Caporale LH, et al. The active site of C3a anaphylatoxin. J Biol Chem. 1980 Nov 25;255(22):10758-63.
Density 1.44 g/cm3
Molecular Formula C35H61N13O10
Molecular Weight 823.94000
Exact Mass 823.46600
PSA 377.83000
LogP 0.40420
Index of Refraction 1.638
Storage condition 2-8℃

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