16142-27-1

16142-27-1 structure

Name: Linsidomine hydrochloride
Chemical Name: 3-Morpholinosydnonimine hydrochloride
CAS Number: 16142-27-1
Molecular Formula: C₆H₁₁ClN₄O₂
Molecular Weight: 206.630
Catalog: Research Areas Cardiovascular Disease
Create Date: 2018-12-17 20:26:16
Modify Date: 2024-01-02 12:31:40
SIN-1 (chloride) is the active metabolite of molsidomine. SIN-1 (chloride) exhibits potent vasorelaxant effect and inhibition of platelet aggregation[1]. SIN-1 (chloride) decreases myocardial necrosis and reperfusion-induced endothelial dysfunction in models of myocardial ischemia-reperfusion[2].

Name	3-Morpholinosydnonimine hydrochloride
Synonyms	3-(4-morpholinyl)-5-sydnone imine hydrochloride [3-(4-Morpholinyl)-1,2,3-oxadiazol-3-ium-5-yl]azanide hydrochloride (1:1) 3-(4-Morpholinyl)sydnone imine hydrochloride Linsidomine hydrochloride SIN-1 hydrochloride T6N DOTJ A- AT5KNOYJ DUM &&sydnone SIN-I HYDROCHLORIDE LINSIDOMINE HCL 3-(4-morpholinyl)-sydnonimine hydrochloride [3-(Morpholin-4-yl)-1,2,3-oxadiazol-3-ium-5-yl]azanide hydrochloride (1:1) MFCD00221615 3-(4-Morpholinyl)sydnone imine hydrochloride LinsidoMine Chlorhydrate 3-morpholinosydnone imine hydrochloride 1,2,3-Oxadiazolium, 5-amino-3-(4-morpholinyl)-, inner salt, hydrochloride (1:1) MolsidoMine IMpurity A SIN-1 SIN-1 CHLORIDE B-HT 933 dihydrochloride 3-morpholino-sydnonimine hydrochloride SIN-1 HCL 3-Morpholinosydnonimine hydrochloride 5-Imino-3-(morpholin-4-yl)-5H-1,2,3-oxadiazol-3-ium-2-ide hydrochloride (1:1) SIN-1 HYDROCHLORIDE EINECS 247-207-4 LINSIDOMINE

Description	SIN-1 (chloride) is the active metabolite of molsidomine. SIN-1 (chloride) exhibits potent vasorelaxant effect and inhibition of platelet aggregation[1]. SIN-1 (chloride) decreases myocardial necrosis and reperfusion-induced endothelial dysfunction in models of myocardial ischemia-reperfusion[2].
Related Catalog	Research Areas >> Cardiovascular Disease
References	[1]. Nishikawa M,et al. Inhibition of platelet aggregation and stimulation of guanylate cyclase by an antianginal agent molsidomine and its metabolites. J Pharmacol Exp Ther. 1982 Jan;220(1):183-90. [2]. Siegfried MR, et al. Cardioprotection and attenuation of endothelial dysfunction by organic nitric oxide donors in myocardial ischemia-reperfusion. J Pharmacol Exp Ther. 1992 Feb;260(2):668-75.

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,280,1968

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,280,1968

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 2,280,1968

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Safety Phrases	S24/25
RIDADR	NONH for all modes of transport
HS Code	2934999090

Precursor 0
DownStream 2
25717-80-0 66564-16-7

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%