34156-56-4

34156-56-4 structure

Name: Phosphonoformic acid trisodium salt hexahydrate
Chemical Name: trisodium phosphonoformate hexahydrate
CAS Number: 34156-56-4
Molecular Formula: CH₁₂Na₃O₁₁P
Molecular Weight: 300.042
Catalog: Organic raw materials Organic phosphine compound
Create Date: 2018-04-08 08:00:00
Modify Date: 2024-01-14 16:33:21
Foscarnet trisodium hexahydrate (Trisodium phosphonatoformate hexahydrate) is a viral DNA polymerase activity inhibitor, leading to reversible suppression of viral replication. Foscarnet trisodium hexahydrate is an antiherpesvirus agent used in cytomegalovirus retinitis[1][2][3].

Name	trisodium phosphonoformate hexahydrate
Synonyms	Phosphoranecarboxylic acid, 1,1-dihydroxy-, oxide, sodium salt, hydrate (1:3:6) Foscarnet Sodium Foscarnet sodium hexahydrate Phosphonoformic acid trisodium salt hexahydrate Sodium dioxidophosphinecarboxylate oxide hydrate (3:1:6) Sodium phosphonatoformate hexahydrate MFCD00150176 phosphonoformicacidtrisodiumsalthexahydrate

Description	Foscarnet trisodium hexahydrate (Trisodium phosphonatoformate hexahydrate) is a viral DNA polymerase activity inhibitor, leading to reversible suppression of viral replication. Foscarnet trisodium hexahydrate is an antiherpesvirus agent used in cytomegalovirus retinitis[1][2][3].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
In Vitro	Phosphonoformic acid inhibit the human cytomegalovirus DNA polymerase (UL54) by mimicking the pyrophosphate leaving group of the nucleotide transfer reaction[1]. Foscarnet sodium (Trisodium phosphonoformate) inhibits Influenza A Victoria (IC50=29 μM), Influenza B HK (IC50=61 μM), and Avian myeloblastosis virus (IC50=5-8 μM),HSV-1, several strains (IC50=0.4-3.5 μM)[2].

CHEMICAL NAME :: Phosphinecarboxylic acid, dihydroxy-, oxide, trisodium salt, hexahydrate

TOXIC EFFECTS :: Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis) Blood - pigmented or nucleated red blood cells Blood - changes in erythrocyte (RBC) count

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 139,324,1996

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	SY8300000