81276-03-1

81276-03-1 structure

Name: 14,15-EET
Chemical Name: (+/-)14,15-epoxyeicosa-5z,8z,11z-trienoic acid
CAS Number: 81276-03-1
Molecular Formula: C₂₀H₃₂O₃
Molecular Weight: 320.46600
Catalog: Research Areas Cardiovascular Disease
Create Date: 2016-06-07 04:06:56
Modify Date: 2024-01-06 22:50:26
14,15-Epoxyeicosatrienoic acid (14,15-EET) is a metabolite of Arachidonic acid (HY-109590). 14,15-Epoxyeicosatrienoic acid is a potent inhibitor of in vivo platelet aggregation. 14,15-Epoxyeicosatrienoic acid facilitates astrocytic Aβ clearance. 14,15-Epoxyeicosatrienoic acid can be used for Alzheimer's Disease research[1][2].

Name	(+/-)14,15-epoxyeicosa-5z,8z,11z-trienoic acid
Synonyms	14,15-Epoxyeicosatrienoic acid 14,15-epoxy-5,8,11-eicosatrienoicacid 14,15-EET

Description	14,15-Epoxyeicosatrienoic acid (14,15-EET) is a metabolite of Arachidonic acid (HY-109590). 14,15-Epoxyeicosatrienoic acid is a potent inhibitor of in vivo platelet aggregation. 14,15-Epoxyeicosatrienoic acid facilitates astrocytic Aβ clearance. 14,15-Epoxyeicosatrienoic acid can be used for Alzheimer's Disease research[1][2].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	14,15-Epoxyeicosatrienoic acid (0-10 μM) 促进原代星形胶质细胞培养物中的 Aβ 摄取[1]。
In Vivo	14,15-Epoxyeicosatrienoic acid (0.3 mg/kg i.v.) 可抑制小鼠脑小动脉中的血小板聚集[2]。 14,15-Epoxyeicosatrienoic acid (200 ng/ml) 注入海马体可逆转 6 个月大的雄性 FAD 小鼠大脑中的 Aβ 沉积[1]。
References	[1]. Chen W, et al. 14,15-Epoxyeicosatrienoic Acid Alleviates Pathology in a Mouse Model of Alzheimer's Disease. J Neurosci. 2020 Oct 14;40(42):8188-8203. [2]. Heizer ML, et al. 14,15-Epoxyeicosatrienoic acid inhibits platelet aggregation in mouse cerebral arterioles. Stroke. 1991 Nov;22(11):1389-93.