71686-01-6

71686-01-6 structure

Name: Calcium 2-oxopentanedioate
Chemical Name: calcium,2-oxopentanedioate
CAS Number: 71686-01-6
Molecular Formula: C₅H₄CaO₅
Molecular Weight: 184.160
Catalog: Signaling Pathways Metabolic Enzyme/Protease Tyrosinase
Create Date: 2018-03-25 08:00:00
Modify Date: 2024-01-02 22:49:07
2-Ketoglutaric acid calcium (Alpha-Ketoglutaric acid calcium) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid calcium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid calcium is a reversible inhibitor of tyrosinase (IC50=15 mM)[1][2].

Name	calcium,2-oxopentanedioate
Synonyms	EINECS 275-843-2 Pentanedioic acid, 2-oxo-, calcium salt (1:1) MFCD02683879 calcium 2-oxidanylidenepentanedioate 2-oxo-glutaric acid,calcium salt 2-Oxo-glutarsaeure,Calcium-Salz Calcium 2-oxopentanedioate Calcium 2-oxoglutarate

Description	2-Ketoglutaric acid calcium (Alpha-Ketoglutaric acid calcium) is an intermediate in the production of ATP or GTP in the Krebs cycle. 2-Ketoglutaric acid calcium also acts as the major carbon skeleton for nitrogen-assimilatory reactions. 2-Ketoglutaric acid calcium is a reversible inhibitor of tyrosinase (IC50=15 mM)[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Metabolic Enzyme/Protease >> Tyrosinase
Target	Tyrosinase:15 mM (IC50) Human Endogenous Metabolite
In Vitro	2-Ketoglutaric acid calcium (Alpha-Ketoglutaric acid calcium) has other physiological capabilities including reduction of ammonia level formed in the lung and general ammonia detoxification, protective role against lipid peroxidation and neuroprotective effect against cyanide poisoning[1]. 2-Ketoglutaric acid calcium acts as precursor for the synthesis of amino acids and nucleotides[2].
References	[1]. Huergo LF, et al. The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite. Microbiol Mol Biol Rev. 2015 Dec;79(4):419-35. [2]. Gou L, et al. The effect of alpha-ketoglutaric acid on tyrosinase activity and conformation: Kinetics and molecular dynamics simulation study. Int J Biol Macromol. 2017 Dec;105(Pt 3):1654-1662.

HS Code	2918300090

HS Code	2918300090
Summary	2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%