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5987-82-6

5987-82-6 structure
5987-82-6 structure
  • Name: benoxinate hydrochloride
  • Chemical Name: oxybuprocaine hydrochloride
  • CAS Number: 5987-82-6
  • Molecular Formula: C17H29ClN2O3
  • Molecular Weight: 344.877
  • Catalog: analytical chemistry Standard Pharmacopoeia Standards and Magazine Standards
  • Create Date: 2018-09-05 10:25:05
  • Modify Date: 2025-08-21 10:33:18
  • Oxybuprocaine hydrochloride (Benoxinate hydrochloride) reversibly blocks sodium channels and prevents propagation of painful nerve impulses in the cornea, conjunctiva, and sclera. Oxybuprocaine hydrochloride is used especially in ophthalmology and otolaryngology[1][2][3].
Name oxybuprocaine hydrochloride
Synonyms Benzoic acid, 4-amino-3-butoxy-, 2-(diethylamino)ethyl ester, hydrochloride (1:1)
2-(Diethylamino)ethyl 4-amino-3-butoxybenzoate hydrochloride (1:1)
Oxybuprocaine HCL
2-(diethylamino)ethyl 4-amino-3-butoxybenzoate,hydrochloride
Benoxinate hydrochloride
2-(Diethylamino)ethyl-4-amino-3-butoxybenzolcarboxylathydrochlorid
MFCD00012512
EINECS 227-808-8
oxybuprocaine hydrochloride
Description Oxybuprocaine hydrochloride (Benoxinate hydrochloride) reversibly blocks sodium channels and prevents propagation of painful nerve impulses in the cornea, conjunctiva, and sclera. Oxybuprocaine hydrochloride is used especially in ophthalmology and otolaryngology[1][2][3].
Related Catalog
In Vivo Oxybuprocaine hydrochloride (Benoxinate hydrochloride; 27.6, 51.7, 103.5, 413.9 μg; s.c.) provides a dose-dependent block to pinpricks in rats[1]. Oxybuprocaine hydrochloride (27.6 μg) produces 100% of sensory/nociceptive block[1]. Animal Model: Male Sprague-Dawley rats (203-253 g)[1] Dosage: 27.6, 51.7, 103.5, 413.9 μg Administration: SC Result: Provided a dose-dependent block to pinpricks.
References

[1]. Chen YW, et al. The Addition of Epinephrine to Proxymetacaine or Oxybuprocaine Solution Increases the Depth and Duration of Cutaneous Analgesia in Rats. Reg Anesth Pain Med. 2016 Sep-Oct;41(5):601-6.

[2]. Chen YW, et al. Adding Dopamine to Proxymetacaine or Oxybuprocaine Solutions Potentiates and Prolongs the Cutaneous Antinociception in Rats. Anesth Analg. 2018 May;126(5):1721-1728.

[3]. Page M, et al. Safety, efficacy, and patient acceptability of lidocaine hydrochloride ophthalmic gel as a topicalocular anesthetic for use in ophthalmic procedures. Clin Ophthalmol. 2009;3:601-9. Epub 2009 Nov 2.
Boiling Point 446.9ºC at 760 mmHg
Melting Point 158 - 162ºC
Molecular Formula C17H29ClN2O3
Molecular Weight 344.877
Flash Point 224.1ºC
Exact Mass 344.186676
PSA 64.79000
LogP 4.32950

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DG1502900
CHEMICAL NAME :
Benzoic acid, 4-amino-3-butoxy-, 2-(diethylamino)ethyl ester, monohydrochloride
CAS REGISTRY NUMBER :
5987-82-6
LAST UPDATED :
199509
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C17-H28-N2-O3.Cl-H
MOLECULAR WEIGHT :
344.93
WISWESSER LINE NOTATION :
4OR BZ EVO2N2&2 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
60 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,154,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5600 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,232,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
42500 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,154,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>6800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,232,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
30 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,232,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
5600 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 24,1957,1974
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
21 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,232,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
4200 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,232,1990
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P305 + P351 + P338
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S22-S26-S36
RIDADR UN 1544PSN2 6.1 / PGIII
RTECS DG15029
HS Code 29225000
HS Code 29225000
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