23811-08-7

23811-08-7 structure

Name: Agarospirol
Chemical Name: hinesol
CAS Number: 23811-08-7
Molecular Formula: C₁₅H₂₆O
Molecular Weight: 222.366
Catalog: Biochemical Chinese herbal medicine ingredients
Create Date: 2018-12-19 06:15:21
Modify Date: 2024-01-02 14:35:18
(-)-Hinesol (Hinesol) is a potent anticancer agent. (-)-Hinesol induces apoptosis and cell cycle arrest at G0/G1 phase. (-)-Hinesol downregulates MEK/ERK pathway and NF-κB pathway and mediates theexpression of cyclin D1, Bax and Bcl-2. (-)-Hinesol has the potential for the research of non–small cell lung cancer[1].

Name	hinesol
Synonyms	2-[(2S,5R,10R)-6,10-Dimethylspiro[4.5]dec-6-en-2-yl]propan-2-ol Agarospirol Spiro[4.5]dec-6-ene-2-methanol, α,α,6,10-tetramethyl-, (2S,5R,10R)- 2-[(2S,5R,10R)-6,10-Dimethylspiro[4.5]dec-6-en-2-yl]-2-propanol

Description	(-)-Hinesol (Hinesol) is a potent anticancer agent. (-)-Hinesol induces apoptosis and cell cycle arrest at G0/G1 phase. (-)-Hinesol downregulates MEK/ERK pathway and NF-κB pathway and mediates theexpression of cyclin D1, Bax and Bcl-2. (-)-Hinesol has the potential for the research of non–small cell lung cancer[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
In Vitro	(-)-Hinesol (0-25 µg/ml; 24, 48 h) shows antiproliferative activity of the A549 and NCI-H1299 cells in a dose- and time-dependent manner[1]. (-)-Hinesol (0, 2, 8 µg/ml; 24 h) induces apoptosis and cell cycle arrest at G0/G1 phase with increases the expression of Bax and decreases the expression of Bcl-2 and cyclin D1[1]. (-)-Hinesol (0, 2, 8 µg/ml; 24 h) decreases the expression of phosphor-ERK1/2, phosphor-MEK1/2, phosphor-IκBα and -p65 level, and shows no change for the total protein levels of IκBα and p65 in A549 cells[1]. Cell Proliferation Assay[1] Cell Line: A549, NCI-H1299 cells Concentration: 0-25 µg/ml Incubation Time: 24, 48 h Result: Inhibited the proliferation of the A549 and NCI-H1299 cells in a dose- and time-dependent manner. Apoptosis Analysis[1] Cell Line: A549 cells Concentration: 0, 2, 8 µg/ml Incubation Time: 24 h Result: Induced apoptosis with the apoptotic cells was increased to 21.2 ± 0.96% and 36 ± 1.04% after treatment with hinesol at 2 and 8 μg/mL, respectively. Western Blot Analysis[1] Cell Line: A549 cells Concentration: 0, 2, 8 µg/ml Incubation Time: 24 h Result: Increased the protein expression of Bax and decreased the expression of Bcl-2. Cell Cycle Analysis[1] Cell Line: A549 cells Concentration: 0, 2, 8 µg/ml Incubation Time: 24 h Result: Showed concentration-dependent increase in the percentage of cell in the G0/G1 phase, and a decrease of the percentage in G2/M phase.
References	[1]. Guo W, et al. The antitumor effect of hinesol, extract from Atractylodes lancea (Thunb.) DC. by proliferation, inhibition, and apoptosis induction via MEK/ERK and NF-κB pathway in non-small cell lung cancer cell lines A549 and NCI-H1299. J Cell Biochem. 2019 Nov;120(11):18600-18607.

Density	1.0±0.1 g/cm3
Boiling Point	312.2±11.0 °C at 760 mmHg
Melting Point	59-60°C (lit.)
Molecular Formula	C₁₅H₂₆O
Molecular Weight	222.366
Flash Point	114.6±15.6 °C
Exact Mass	222.198364
PSA	20.23000
LogP	4.67
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.505

HS Code	2906199090

HS Code	2906199090
Summary	2906199090. cyclanic, cyclenic or cyclotherpenic alcohols. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%