Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: methacholine bromide
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Purity: 98.0%
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333-31-3

333-31-3 structure

Name: UNII:M73AI9718D
Chemical Name: methacholine bromide
CAS Number: 333-31-3
Molecular Formula: C₈H₁₈BrNO₂
Molecular Weight: 240.138
Catalog: Signaling Pathways GPCR/G Protein mAChR
Create Date: 2018-04-26 08:00:00
Modify Date: 2026-07-02 20:38:49
Methacholine (Acetyl-β-methylcholine) bromide is a potent muscarinic-3 (M3) agonist. Methacholine bromide acts directly on acetylcholine receptors on smooth muscle causing bronchoconstriction and airway narrowing. Methacholine bromide shows a high sensitivity to identify bronchial hyperresponsiveness (BHR). Methacholine bromide can be used to measure airway hyperresponsiveness (AHR) as a diagnostic aid in the assessment of individuals with asthma-like symptoms and normal resting expiratory flow rates[1][2][3][4].

Name	methacholine bromide
Synonyms	ACETYL-BETA-METHYLCHOLINE BROMIDE 2-Acetoxy-N,N,N-trimethyl-1-propanaminium bromide metacholine TRIMETHYL-B-ACETOXYPROPYLAMMONIUM BROMIDE ACETYL-B-METHYLCHOLINE BROMIDE Acetyl-β-methylcholine bromide O-Acetyl-β-methylcholine bromide rac-(R*)-O-Acetyl-β-methylcholine MECHOLYL BROMIDE ACETYL SS-METHYLCHOLINE BROMIDE METHACHOLINE BROMIDE Trimethyl-beta-acetoxypropylammonium bromide 1-Propanaminium, 2-(acetyloxy)-N,N,N-trimethyl-, bromide (1:1) Methacholine 1-Propanaminium, 2-(acetyloxy)-N,N,N-trimethyl-, bromide 2-Acetoxy-N,N,N-trimethylpropan-1-aminium bromide METHYLCHOLINE BROMIDE (2-HYDROXYPROPYL)TRIMET MethacholineBromide> (2-ACETOXYPROPYL)TRIMETHYLAMMONIUM BROMIDE Acetyl-beta-methylcholine bromide O-Acetyl-beta-methylcholine Bromide Mecholyl Bromide Acetyl-&beta 1-Propanaminium,2-(acetyloxy)-N,N,N-trimethyl-,bromide O-Acetyl-β-methylcholine Bromide beta-Methylacetylcholine bromide ACETYL-B-METHYLCHOLINE BROMIDECRYSTALLIN E acetyl á-methylcholine bromide ACETYL-β-METHYLCHOLINEBROMID 2(Acetyloxy)-N,N,N-triMethyl-1-propanaMiniuM broMide MFCD00011816 TriMethyl-β-acetoxypropylaMMoniuM broMide (2-HYDROXYPROPYL)TRIMETHYLAMMONIUM BROMIDE ACETATE O-ACETYL-BETA-METHYLCHOLINE BROMIDE 2-acetoxy-n,n,n-trimethylpropan-1-aminium bromide Acetyl β-methylcholine bromide EINECS 206-372-2 2-(acetyloxy)-n,n,n-trimethyl-1-propanaminiubromide Acetyl choline Methyl broMide -β

Description	Methacholine (Acetyl-β-methylcholine) bromide is a potent muscarinic-3 (M3) agonist. Methacholine bromide acts directly on acetylcholine receptors on smooth muscle causing bronchoconstriction and airway narrowing. Methacholine bromide shows a high sensitivity to identify bronchial hyperresponsiveness (BHR). Methacholine bromide can be used to measure airway hyperresponsiveness (AHR) as a diagnostic aid in the assessment of individuals with asthma-like symptoms and normal resting expiratory flow rates[1][2][3][4].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> mAChR
In Vivo	Methacholine bromide (0.5 µg/kg plus 5 µg/kg/min for 30 min) induces bronchoconstriction in dogs[4]. Methacholine bromide (0.5 mg/kg; i.v.) induces bronchoconstriction was inhibited by bradykinin (4-40 µg/kg; i.v.) in a a dose-dependent manner in mouse[5]. Animal Model: 9-week female BALB/c mice[6] Dosage: 0.03, 0.1, 0.3, 1 mg/kg Administration: I.v Result: Induced severe bronchoconstriction.
References	[1]. Cohen J, et al. Relationship between airway responsiveness to neurokinin A and methacholine in asthma. Pulm Pharmacol Ther. 2005;18(3):171-176. [2]. Anderson SD, et al. Comparison of mannitol and methacholine to predict exercise-induced bronchoconstriction and a clinical diagnosis of asthma. Respir Res. 2009;10(1):4. Published 2009 Jan 23. [3]. Cockcroft DW. Methacholine challenge methods. Chest. 2008;134(4):678-680. [4]. Kabara S, et al. Differential effects of thiopental on methacholine- and serotonin-induced bronchoconstriction in dogs. Br J Anaesth. 2003 Sep;91(3):379-84. [5]. Folkerts G, et al. Bradykinin causes inhibition of methacholine-induced bronchoconstriction in vivo in mice. Naunyn Schmiedebergs Arch Pharmacol. 2001 Jul;364(1):53-8. [6]. Vitorasso RL, et al. Methacholine dose response curve and acceptability criteria of respiratory mechanics modeling. Exp Lung Res. 2020 Feb-Mar;46(1-2):23-31.

Melting Point	147-149ºC(lit.)
Molecular Formula	C₈H₁₈BrNO₂
Molecular Weight	240.138
Exact Mass	239.052078
PSA	26.30000

Hazard Codes	Xi: Irritant;
Risk Phrases	36/37/38
Safety Phrases	26-36
HS Code	2923900090

75-50-3

333-31-3

Literature: Journal of Pharmacology and Experimental Therapeutics, , vol. 51, p. 258 Chem. Zentralbl., , vol. 106, # I p. 436

74-83-9

108-16-7

108-24-7

333-31-3

Literature: US2192204 , ;

Precursor 4
75-50-3 74-83-9 108-16-7 108-24-7
DownStream 0

HS Code	2923900090
Summary	2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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