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Product Name: Ethanamine,2-chloro-N,N-bis(2-chloroethyl)-, hydrochloride (1:1)
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817-09-4

817-09-4 structure

Name: Trichlormethine (hydrochloride)
Chemical Name: 2-chloro-N,N-bis(2-chloroethyl)ethanamine,hydrochloride
CAS Number: 817-09-4
Molecular Formula: C₆H₁₃Cl₄N
Molecular Weight: 240.98600
Catalog: Organic raw materials Amino compound Acyclic monoamines, polyamines and their derivatives and salts
Create Date: 2018-02-26 08:00:00
Modify Date: 2026-07-02 11:20:59
Trichlormethine hydrochloride is a cytostatic agent in the treatment of cancer and arthritis; shows carcinogenic effects to humans.

Name	2-chloro-N,N-bis(2-chloroethyl)ethanamine,hydrochloride
Synonyms	tris-n-lost Trazodone Impurity QZT-SM-4-Z3 HCl Trichlormethin Lekamin r-47 TRIS(2-CHLOROETHYL)AMINE HYDROCHLORIDE Tris(2-chloroethyl)amineHCl 2,2’,2’’-trichloro-triethylaminhydrochloride MFCD00012520 Tris(2-chloroethyl)amine hydrochloride hn3hydrochloride tri-(2-chloroethyl)aminehydrochloride trichlor-triaethylamin-hydrochlorid Trimitan trichlormethine Trazodone impurity QZT-SM-4-Z3 hydrochloride 2-chloro-n,n-bis(2-chloroethyl)-ethanaminhydrochloride TRIS(2-CHLOROETHYL)AMINE HYDROCHLORIDE ISO 9001：2015 REACH B,B',B''-TRICHLOROTRIETHYLAMINE HYDROCHLORIDE Hn3 hcl Trichlormethine HCl Vortioxetine Impurity 68 HCl TRICHLOROTRIETHYLAMINEHYDROCHLORIDE 2,2',2''-TRICHLOROTRIETHYLAMINE HYDROCHLORIDE tris(beta-chloroethyl)aminehydrochloride nsc-30211 tris(2-chloroethyl)ammoniumchloride sk-100 tris(2-chloroethyl)ammonium hydrochloride Ethanamine,2-chloro-N,N-bis[2-chloroethyl]-,hydrochloride Trimustine hydrochloride EINECS 212-442-3 trillekamin 2,2',2''-Trichlortriethylamin-hydrochlorid HN3 hydrochloride trimitan Trillekamin Sinalost Ethanamine,2-chloro-N,N-bis(2-chloroethyl)-, hydrochloride (1:1) trichlormethiniumchloride Trimustine Tris(2-chloroethyl)amine hydrochloride2,2',2''-Trichlorotriethylamine hydrochloride tris(2-chloroethyl)aminemonohydrochloride lekamin tri(beta-chloroethyl)aminehydrochloride 2-chloro-N,N-bis(2-chloroethyl)ethanamine hydrochloride trimustine sinalost tris(2-chloro-ethyl)amine hydrochloride salt

Description	Trichlormethine hydrochloride is a cytostatic agent in the treatment of cancer and arthritis; shows carcinogenic effects to humans.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer
In Vitro	Trichlormethine could be detected at a surface coverage of 0.01 monolayer, which corresponds to 20 ppm (mass/mass) for a soil having a surface area of 2.2 m2/g. TEA, the exhaustive hydrolysis product of trichlormethine, is detected at a surface coverage of 0.001 monolayer, which corresponds to 0.86 ppm[1].
In Vivo	Trichlormethine hydrochloride carries a genetic risk for the postmeiotic stages of spermatogenesis and is responsible for interference in the morphology of sperm heads through its action on spermatocytes. The toxic effects of trichlormethine hydrochloride are found to influence the body weight of mice, to reduce the relative weight of the testes, to damage spermatogenesis in the seminiferous tubules, to be responsible for an appearance of multinucleate cells in the epididymides, and for an increased rate of abnormality of the heads of fully mature spermatozoa[2].
Animal Admin	Mice: The genetic effect of the cytostatic trichlormethine hydrochloride is assessed after a 1-week administration using the dominant lethal mutation test (DLM) and the sperm abnormality test. The dosage is 0.5 mg/kg for 7 consecutive days, an equivalent of the human therapeutic dosage. Simultaneously, the cytostatic's direct toxic effect on male sex organs is assessed[2].
References	[1]. Gresham GL, et al. Identification of the nitrogen-based blister agents bis(2-chloroethyl)methylamine (HN-2) and tris(2-chloroethyl)amine (HN-3) and their hydrolysis products on soil using ion trap secondary ion mass spectrometry. J Mass Spectrom. 2000 Dec;35(12):1460-9. [2]. Sýkora I, et al. Trichlormethine hydrochloride and correlation of its mutagenic and toxic effects on male germ cells in mice. Mutat Res. 1992 Apr;266(2):291-7.

Boiling Point	156.2ºC at 760 mmHg
Melting Point	127-130ºC(lit.)
Molecular Formula	C₆H₁₃Cl₄N
Molecular Weight	240.98600
Flash Point	48.3ºC
Exact Mass	238.98000
PSA	3.24000
LogP	2.80680
Storage condition	Poison room

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YE2800000

CHEMICAL NAME :: Triethylamine, 2,2',2''-trichloro-, hydrochloride

CAS REGISTRY NUMBER :: 817-09-4

LAST UPDATED :: 199512

DATA ITEMS CITED :: 27

MOLECULAR FORMULA :: C6-H12-Cl3-N.Cl-H

MOLECULAR WEIGHT :: 241.00

WISWESSER LINE NOTATION :: G2N2G2G &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 214 ug/kg

TOXIC EFFECTS :: Blood - leukopenia

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human

DOSE/DURATION :: 30 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - anorexia (human) Gastrointestinal - nausea or vomiting

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human

DOSE/DURATION :: 100 ug/kg

TOXIC EFFECTS :: Behavioral - headache Vascular - thrombosis distant from injection site Gastrointestinal - nausea or vomiting

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 5 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 750 ug/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 700 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1100 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1600 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD75 - Lethal Dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 1 mg/kg

TOXIC EFFECTS :: Gastrointestinal - ulceration or bleeding from small intestine Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2 mg/kg

TOXIC EFFECTS :: Gastrointestinal - changes in structure or function of salivary glands

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10 mg/kg/9W-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors Tumorigenic - tumors at site of application

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 2400 ug/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 1500 ug/kg

SEX/DURATION :: male 1 day(s) pre-mating

TOXIC EFFECTS :: Reproductive - Paternal Effects - testes, epididymis, sperm duct

TYPE OF TEST :: DNA damage

TYPE OF TEST :: Dominant lethal test

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 3500 ug/kg/7D (Continuous)

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 266,291,1992 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 50,143,1990 IARC Cancer Review:Animal Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 9,229,1975 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 9,229,1975 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 50,143,1990 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 50,143,1990

Symbol	GHS05, GHS06, GHS08
Signal Word	Danger
Hazard Statements	H300-H314-H351
Precautionary Statements	P264-P280-P305 + P351 + P338-P310
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T+: Very toxic;Xi: Irritant;
Risk Phrases	R26/27/28;R33;R40
Safety Phrases	S23-S24/25
RIDADR	UN 2928 6.1/PG 1
WGK Germany	3
RTECS	YE2800000
Packaging Group	II
Hazard Class	6.1(a)
HS Code	2921199090

102-71-6

~94%

817-09-4

Literature: Singh, Ashutosh S.; Sun, Shih-Sheng Journal of Organic Chemistry, 2012 , vol. 77, # 4 p. 1880 - 1890

637-39-8

~92%

817-09-4

Literature: Ichikawa, Satoshi; Ueno, Hideaki; Sunadome, Takuya; Sato, Kousuke; Matsuda, Akira Organic Letters, 2013 , vol. 15, # 3 p. 694 - 697

Precursor 2
102-71-6 637-39-8
DownStream 9
31295-54-2 280-57-9 104-19-8 140-31-8
107-20-0 63915-60-6 84928-99-4 98545-15-4
4201-86-9

HS Code	2921199090
Summary	2921199090 other acyclic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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