174664-65-4

174664-65-4 structure

Name: Carboxycinnamic acid bishydroxamide
Chemical Name: m-Carboxycinnamic Acid Bishydroxamide
CAS Number: 174664-65-4
Molecular Formula: C₁₀H₁₀N₂O₄
Molecular Weight: 222.20
Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
Create Date: 2016-12-08 02:26:28
Modify Date: 2024-01-05 11:05:47
m-Carboxycinnamic acid bishydroxamide is a potent HDAC inhibitor, exhibiting ID50 values of 10 and 70 nM in vitro for HDAC1 and HDAC3, respectively[1]. m-Carboxycinnamic acid bishydroxamide also induces apoptosis and suppresses tumor growth[2].

Name	m-Carboxycinnamic Acid Bishydroxamide
Synonyms	N-hydroxy-3-[3-(hydroxyamino)-3-oxoprop-1-enyl]benzamide Benzamide, N-hydroxy-3-[(1E)-3-(hydroxyamino)-3-oxo-1-propen-1-yl]- N-Hydroxy-3-[(1E)-3-(hydroxyamino)-3-oxo-1-propen-1-yl]benzamide

Description	m-Carboxycinnamic acid bishydroxamide is a potent HDAC inhibitor, exhibiting ID50 values of 10 and 70 nM in vitro for HDAC1 and HDAC3, respectively[1]. m-Carboxycinnamic acid bishydroxamide also induces apoptosis and suppresses tumor growth[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
References	[1]. Richon VM, et al. A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3003-7. [2]. Glick RD, et al. Hybrid polar histone deacetylase inhibitor induces apoptosis and CD95/CD95 ligand expression in human neuroblastoma. Cancer Res. 1999 Sep 1;59(17):4392-9.