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125926-17-2

125926-17-2 structure
125926-17-2 structure
  • Name: Sarpogrelate
  • Chemical Name: 4-[1-(dimethylamino)-3-[2-[2-(3-methoxyphenyl)ethyl]phenoxy]propan-2-yl]oxy-4-oxobutanoic acid
  • CAS Number: 125926-17-2
  • Molecular Formula: C24H31NO6
  • Molecular Weight: 429.506
  • Catalog: API Blood system medication Anticoagulant and antiplatelet drugs
  • Create Date: 2018-05-09 08:00:00
  • Modify Date: 2025-08-23 23:19:24
  • Sarpogrelate (MCI-9042) is a new, specific orally active 5-HT2 receptor antagonist, Sarpogrelate (MCI-9042) increases platelet aggregation and has hemostasis effect, and can be used for the research of Buerger’s disease[1].

Name 4-[1-(dimethylamino)-3-[2-[2-(3-methoxyphenyl)ethyl]phenoxy]propan-2-yl]oxy-4-oxobutanoic acid
Synonyms UNII-19P708E787
Sarpogrelate Hydrochloride
Butanedioic acid, mono[2-(dimethylamino)-1-[[2-[2-(3-methoxyphenyl)ethyl]phenoxy]methyl]ethyl] ester
4-{[1-(Dimethylamino)-3-{2-[2-(3-methoxyphenyl)ethyl]phenoxy}-2-propanyl]oxy}-4-oxobutanoic acid
Sarpogrelate
Description Sarpogrelate (MCI-9042) is a new, specific orally active 5-HT2 receptor antagonist, Sarpogrelate (MCI-9042) increases platelet aggregation and has hemostasis effect, and can be used for the research of Buerger’s disease[1].
Related Catalog
Target

5-HT2 Receptor

In Vitro Sarpogrelate (MCI-9042) induces a significant decrease in plasma serotonin (5-HT) concentration and after 2 weeks increases significantly the concentration of whole blood 5-HT. Sarpogrelate (MCI-9042) increases significantly plasma tryptophan concentration after 2 and 4 weeks, and no changes in plasma 5-HIAA concentration. Sarpogrelate (MCI-9042) also has a tendency to increase the concentration of whole blood tryptophan concentration, did not show significant changes in platelet aggregation induced by ADP and collagen. Sarpogrelate (MCI-9042) increases significantly platelet aggregation induced by serotonin after 2 weeks[1].
References

[1]. A Rydzewski, et al. The effect of a 5HT2 receptor antagonist sarpogrelate (MCI-9042) treatment on platelet function in Buerger's disease. Thromb Res. 1996 Dec 15;84(6):445-52.

Density 1.2±0.1 g/cm3
Boiling Point 585.9±50.0 °C at 760 mmHg
Molecular Formula C24H31NO6
Molecular Weight 429.506
Flash Point 308.1±30.1 °C
Exact Mass 429.215149
PSA 85.30000
LogP 3.68
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.551
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