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7008-42-6

7008-42-6 structure
7008-42-6 structure
Name acronycine
Synonyms Acronina [INN-Spanish]
6-methoxy-3,3,12-trimethylpyrano[2,3-c]acridin-7-one
Acromycine
6-methoxy-3,3,12-trimethyl-3,12-dihydro-pyrano[2,3-c]acridin-7-one
3H-Pyrano[2,3-c]acridin-7-ol, 7,12-dihydro-6-methoxy-3,3,12-trimethyl-
6-Methoxy-3,3,12-trimethyl-7,12-dihydro-3H-pyrano[2,3-c]acridin-7-ol
6-Methoxy-3,3,12-trimethyl-3,12-dihydro-pyrano[2,3-c]acridin-7-on
ACRONYCINE
Acronine
Acroninum [INN-Latin]
4-27-00-03622
Density 1.2±0.1 g/cm3
Boiling Point 489.8±45.0 °C at 760 mmHg
Melting Point 175-176ºC
Molecular Formula C20H19NO3
Molecular Weight 323.386
Flash Point 250.0±28.7 °C
Exact Mass 323.152130
PSA 40.46000
LogP 2.99
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.612

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UQ0330000
CHEMICAL NAME :
7H-Pyrano(2,3-c)acridin-7-one, 3,12-dihydro-6-methoxy-3,3,12-trimethyl-
CAS REGISTRY NUMBER :
7008-42-6
BEILSTEIN REFERENCE NO. :
0312954
LAST UPDATED :
199612
DATA ITEMS CITED :
13
MOLECULAR FORMULA :
C20-H19-N-O3
MOLECULAR WEIGHT :
321.40

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
522 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
613 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Brain and Coverings - recordings from specific areas of CNS Behavioral - somnolence (general depressed activity)
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1170 mg/kg/1Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Musculoskeletal - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
585 mg/kg/1Y-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1800 mg/kg/1Y-I
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Tumorigenic - tumors at site of application
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
530 mg/kg/8W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent - mouse Fibroblast
DOSE/DURATION :
10 mg/L/24H
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,1549,1977

Chemsrc provides CAS#:7008-42-6 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 7008-42-6 | Chemsrc address: https://m.chemsrc.com/en/baike/336430.html

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