7H-Pyrano[2,3-c]acridin-7-one,3,12-dihydro-6-methoxy-3,3,12-trimethyl-

Modify Date: 2024-01-09 21:04:38

7H-Pyrano[2,3-c]acridin-7-one,3,12-dihydro-6-methoxy-3,3,12-trimethyl- structure	Common Name	7H-Pyrano[2,3-c]acridin-7-one,3,12-dihydro-6-methoxy-3,3,12-trimethyl-
	CAS Number	7008-42-6	Molecular Weight	323.386
	Density	1.2±0.1 g/cm3	Boiling Point	489.8±45.0 °C at 760 mmHg
	Molecular Formula	C₂₀H₁₉NO₃	Melting Point	175-176ºC
	MSDS	N/A	Flash Point	250.0±28.7 °C

Name	acronycine
Synonym	More Synonyms

Density	1.2±0.1 g/cm3
Boiling Point	489.8±45.0 °C at 760 mmHg
Melting Point	175-176ºC
Molecular Formula	C₂₀H₁₉NO₃
Molecular Weight	323.386
Flash Point	250.0±28.7 °C
Exact Mass	323.152130
PSA	40.46000
LogP	2.99
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.612

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ0330000

CHEMICAL NAME :: 7H-Pyrano(2,3-c)acridin-7-one, 3,12-dihydro-6-methoxy-3,3,12-trimethyl-

CAS REGISTRY NUMBER :: 7008-42-6

BEILSTEIN REFERENCE NO. :: 0312954

LAST UPDATED :: 199612

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C20-H19-N-O3

MOLECULAR WEIGHT :: 321.40

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 522 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 613 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Brain and Coverings - recordings from specific areas of CNS Behavioral - somnolence (general depressed activity)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1170 mg/kg/1Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Musculoskeletal - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 585 mg/kg/1Y-I

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1800 mg/kg/1Y-I

TOXIC EFFECTS :: Tumorigenic - Carcinogenic by RTECS criteria Tumorigenic - tumors at site of application

TYPE OF TEST :: TD - Toxic dose (other than lowest)

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 530 mg/kg/8W-I

TOXIC EFFECTS :: Tumorigenic - equivocal tumorigenic agent by RTECS criteria Lungs, Thorax, or Respiration - tumors

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - mouse Fibroblast

DOSE/DURATION :: 10 mg/L/24H

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 27,1549,1977

Precursor 9
CAS#:13396-93-5 7H-Pyrano(2,3-c... CAS#:74-88-4 methyl iodide CAS#:2190-48-9 3-CHLORO-3-METH... CAS#:20324-10-1 1,3-Dihydroxyac...
CAS#:79228-40-3 6-(2-N-methylam... CAS#:1111-97-3 3-Chloro-3-meth... CAS#:500-99-2 3,5-Dimethoxyphenol CAS#:21421-66-9 5,7-dimethoxy-2...
CAS#:79228-37-8 6-(2-N-acetylam...
DownStream 5
CAS#:13161-80-3 6-methoxy-3,3,1... CAS#:70509-94-3 6-Hydroxy-3,3,1... CAS#:7095-42-3 7H-Pyrano[2,3-c... CAS#:82791-69-3 Thioacronycine
CAS#:52661-35-5 9-Acetoxyacronycine

Acronina [INN-Spanish]

6-methoxy-3,3,12-trimethylpyrano[2,3-c]acridin-7-one

Acromycine

6-methoxy-3,3,12-trimethyl-3,12-dihydro-pyrano[2,3-c]acridin-7-one

3H-Pyrano[2,3-c]acridin-7-ol, 7,12-dihydro-6-methoxy-3,3,12-trimethyl-

6-Methoxy-3,3,12-trimethyl-7,12-dihydro-3H-pyrano[2,3-c]acridin-7-ol

6-Methoxy-3,3,12-trimethyl-3,12-dihydro-pyrano[2,3-c]acridin-7-on

ACRONYCINE

Acronine

Acroninum [INN-Latin]

4-27-00-03622