87691-91-6

87691-91-6 structure

Name: Tiospirone
Chemical Name: 8-[4-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]butyl]-8-azaspiro[4.5]decane-7,9-dione
CAS Number: 87691-91-6
Molecular Formula: C₂₄H₃₂N₄O₂S
Molecular Weight: 440.60100
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2018-08-24 19:43:50
Modify Date: 2024-01-06 14:48:53
Tiospirone is a 5-HT2 receptor antagonist with affinity for D2, 5-HT1a, and 5-HT7, and sigma receptors. Tiospirone decreases consumption of ethanol while increasing food intake of rats. Tiospirone can also reduce the reinforcing properties of Cocaine exhibited in the conditioned place preference paradigm[1][2].

Name	8-[4-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]butyl]-8-azaspiro[4.5]decane-7,9-dione
Synonyms	Tiospirona [Spanish] tiaspirone Tiospirone [INN] Tiospironum [Latin] [14C]-Tiospirone Tiospironum Tiospirona 8-{4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl}-8-azaspiro[4.5]decane-7,9-dione 8-Azaspiro(4,5)decane-7,9-dione,8-(4-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)butyl) TIOSPIRONE

Description	Tiospirone is a 5-HT2 receptor antagonist with affinity for D2, 5-HT1a, and 5-HT7, and sigma receptors. Tiospirone decreases consumption of ethanol while increasing food intake of rats. Tiospirone can also reduce the reinforcing properties of Cocaine exhibited in the conditioned place preference paradigm[1][2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
References	[1]. Arolfo MP, et, al. Effects of amperozide and tiospirone, atypical antipsychotic 5-HT2 drugs, on food-reinforced behavior in rats. Physiol Behav. 1999 Dec;68(1-2):93-8. [2]. Arolfo MP, et, al. Tiospirone and the reinforcing effects of cocaine in the conditioned place preference paradigm in rats. J Pharm Pharmacol. 2000 Aug;52(8):977-81.