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19186-33-5

19186-33-5 structure

19186-33-5 structure

Name: Aristeromycin
Chemical Name: Aristeromycin
CAS Number: 19186-33-5
Molecular Formula: C₁₁H₁₅N₅O₃
Molecular Weight: 265.26900
Catalog: Research Areas Cancer
Create Date: 2018-05-03 08:00:00
Modify Date: 2026-07-04 08:52:41
Aristeromycin, an adenosine analog, is an antibiotic and a potent S-adenosylhomocysteine hydrolase (AHCY) inhibitor[1][2].

Name	Aristeromycin
Synonyms	1,2-cyclopentanediol,3-(6-amino-9h-purin-9-yl)-5-(hydroxymethyl)-,(1r,2s,3r,5 Cycloadenosine (1r,2s,3r,5r)-3-(6-amino-9h-purin-9-yl)-5-(hydroxymethyl)-1,2-cyclopentanedi Cbocyclic adenosine ISTEROMYCIN 9-[2,3-DIHYDROXY-4-(HYDROXYMETHYL)CYCLOPENTYL]ADENINE 4'-O-Cbaadenosine 4'-O-Carbaadenosine 3-isteromycin 1,2-Cyclopentanediol, 5-(6-amino-9H-purin-9-yl)-3-(hydroxymethyl)-, (1S,2R,3R,5R) (-)-isteromycin (1R,2S,3R,5R)-3-(6-Amino-9H-purin-9-yl)-5-(hydroxymethyl)-1,2-cyclopentanediol carbocyclic adenosine (1R,2S,3R,5R)-3-(6-amino-9H-purin-9-yl)-5-(hydroxymethyl)cyclopentane-1,2-diol

Description	Aristeromycin, an adenosine analog, is an antibiotic and a potent S-adenosylhomocysteine hydrolase (AHCY) inhibitor[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	S-adenosylhomocysteine hydrolase[1]
In Vitro	The IC50 value of Aristeromycin against AHCY is 38.5 nM at 50 μM SAH (approximately equal to the Km: 48 μM), but 271 nM at 1000 µM SAH (20× Km). With 60 min of preincubation, the mean IC50 value of Aristeromycin at 50 μM SAH is 12.7 nM[1]. Aristeromycin has IC50 values of 3.2 μM for LNCaP-FGC cell growth and 0.88 μM for LNCaP-hr cell growth[1]. At least in part, Aristeromycin can regulate oncogenic EZH2 expression by inducing miR-26a[1].
References	[1]. Uchiyama N, et al. Aristeromycin and DZNeP cause growth inhibition of prostate cancer via induction of mir-26a. Eur J Pharmacol. 2017 Oct 5;812:138-146. [2]. Ishikura T, et al. Inhibition of S-adenosylhomocysteine hydrolase by purine nucleoside analogues. Nucleic Acids Symp Ser. 1983;(12):119-22.

Density	1.92g/cm3
Boiling Point	595.1ºC at 760mmHg
Molecular Formula	C₁₁H₁₅N₅O₃
Molecular Weight	265.26900
Flash Point	313.7ºC
Exact Mass	265.11700
PSA	130.31000
Vapour Pressure	5.19E-15mmHg at 25°C
Index of Refraction	1.881
Storage condition	-20°C

WGK Germany	3
RTECS	GY4250000

Precursor 4
84955-45-3 85026-57-9 84955-46-4 683276-43-9
DownStream 1
16975-94-3

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