CHEMICAL IDENTIFICATION
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RTECS NUMBER :
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NT4037000
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CHEMICAL NAME :
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Isoprene
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CAS REGISTRY NUMBER :
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78-79-5
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LAST UPDATED :
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199712
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DATA ITEMS CITED :
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20
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MOLECULAR FORMULA :
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C5-H8
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MOLECULAR WEIGHT :
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68.13
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WISWESSER LINE NOTATION :
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1UY1&1U1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
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TYPE OF TEST :
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LC50 - Lethal concentration, 50 percent kill
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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180 gm/m3/4H
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TOXIC EFFECTS :
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Behavioral - general anesthetic Lungs, Thorax, or Respiration - respiratory depression
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TYPE OF TEST :
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LC50 - Lethal concentration, 50 percent kill
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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139 gm/m3/2H
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TOXIC EFFECTS :
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Lungs, Thorax, or Respiration - other changes
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TYPE OF TEST :
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TDLo - Lowest published toxic dose
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ROUTE OF EXPOSURE :
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Oral
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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157 mg/kg/9W-C
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TOXIC EFFECTS :
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Behavioral - alteration of classical conditioning
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - rat
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DOSE/DURATION :
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3400 mg/m3/22W-I
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TOXIC EFFECTS :
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Brain and Coverings - changes in brain weight Lungs, Thorax, or Respiration - changes in lung weight Kidney, Ureter, Bladder - changes in kidney weight
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - mouse
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DOSE/DURATION :
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3400 mg/m3/17W-I
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TOXIC EFFECTS :
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Behavioral - changes in psychophysiological tests
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TYPE OF TEST :
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TCLo - Lowest published toxic concentration
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ROUTE OF EXPOSURE :
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Inhalation
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SPECIES OBSERVED :
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Rodent - guinea pig
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DOSE/DURATION :
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3400 mg/m3/17W-I
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TOXIC EFFECTS :
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Behavioral - alteration of classical conditioning Blood - changes in leukocyte (WBC) count
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TYPE OF TEST :
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Micronucleus test
MUTATION DATA
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TEST SYSTEM :
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Rodent - mouse
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DOSE/DURATION :
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438 ppm/6H/12D (Continuous)
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REFERENCE :
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MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986- Volume(issue)/page/year: 3,141,1988 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 60,215,1994 IARC Cancer Review:Human Inadequate Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 60,215,1994 IARC Cancer Review:Group 2B IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 60,215,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-POLAND:TWA 100 mg/m3 JAN 1993 OEL-RUSSIA:STEL 40 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 40940 No. of Facilities: 2278 (estimated) No. of Industries: 36 No. of Occupations: 43 No. of Employees: 58102 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 40940 No. of Facilities: 123 (estimated) No. of Industries: 6 No. of Occupations: 15 No. of Employees: 3703 (estimated) No. of Female Employees: 578 (estimated)
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