328-38-1

328-38-1 structure

Name: H-D-Leu-OH
Chemical Name: D-leucine
CAS Number: 328-38-1
Molecular Formula: C₆H₁₃NO₂
Molecular Weight: 131.173
Catalog: Biochemical Amino acids and their derivatives --amino acid
Create Date: 2018-08-09 20:27:33
Modify Date: 2026-07-02 11:51:01
D-Leucine is a more potent anti-seizure agent than L-leucine. D-leucine potently terminates seizures even after the onset of seizure activity. D-leucine, but not L-leucine, reduces long-term potentiation but had no effect on basal synaptic transmission in vitro[1].

Name	D-leucine
Synonyms	D-Leucine, R H-D-LEU-OH D-Leucine H-D-Leu-OH (D-Leucine) D-Leucine Vetec(TM) ade (R)-2-Amino-4-methylpentanoic acid D-2-Amino-4-methylpentanoic acid //BP d-leucin (2R)-2-Amino-4-methylpentanoic acid (2R)-2-amino-4-methylpentanoic acid ent-1 D-Leu-OH D-Homo-valine (R)-2-AMINO-4-METHYLVALERIC ACID (R)-2-Amino-4-methyl-pentanoic acid EINECS 206-327-7 (R)-(-)-LEUCINE D-LACTULOSE OCTAACETATE D-Leucine/CH78985 D -Leucine D-LEU D-Leucine (anhydrous assay) leucine D-Leucine (9CI, ACI) (2R)-2-Amino-4-methylpentanoic acid, (2R)-2-Amino-4-methylvaleric acid, H-D-Leu-OH D-2-AMINO-4-METHYLPENTANOIC ACID MFCD00063088 H-D-LEUCINE dextro-leucine D-Leucine> H-Leu-OH (R)-2-AMINO-4-METHYLPENTANOIC ACID D-Leucine ReagentPlus(R) D-2-Amino-4-methylvaleric acid D-LeuClne D-LEUCINE extrapure D-LEUCINE D-LEUCINE, ( EE/GLC) (R)-LEUCINE Leucine, D- (8CI) D-2-Amino-4-methylpentanoicacid D-HOMO-VALINE D-Leucine (9CI) Leucine, D

Description	D-Leucine is a more potent anti-seizure agent than L-leucine. D-leucine potently terminates seizures even after the onset of seizure activity. D-leucine, but not L-leucine, reduces long-term potentiation but had no effect on basal synaptic transmission in vitro[1].
Related Catalog	Research Areas >> Neurological Disease
Target	Human Endogenous Metabolite
In Vitro	In a screen of candidate neuronal receptors, D-leucine failed to compete for binding by cognate ligands, potentially suggesting a novel target. Even at low doses, D-leucine suppressed ongoing seizures at least as effectively as diazepam but without sedative effects. These studies raise the possibility that D-leucine may represent a new class of anti-seizure agents, and that D-leucine may have a previously unknown function in eukaryotes[1].
References	[1]. Xiaoyu Cao, et al. Combination of PARP Inhibitor and Temozolomide to Suppress Chordoma Progression. J Mol Med (Berl). 2019 Aug;97(8):1183-1193

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951- Volume(issue)/page/year: 64,319,1956

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	22-24/25-36-26
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	OH2840000
HS Code	2922499990

HS Code	2922499990
Summary	HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%