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101-31-5

101-31-5 structure
101-31-5 structure
  • Name: Hyoscyamine
  • Chemical Name: (S)-atropine
  • CAS Number: 101-31-5
  • Molecular Formula: C17H23NO3
  • Molecular Weight: 289.369
  • Catalog: API Digestive system medication Gastrointestinal expectorant
  • Create Date: 2018-02-06 08:00:00
  • Modify Date: 2024-01-02 16:53:02
  • L-Hyoscyamine is a chemical compound, a tropane alkaloid it is the levo-isomer to atropine.Target: mAChRHyoscyamine is a chemical compound, a tropane alkaloid it is the levo-isomer to atropine. It is a secondary metabolite of some plants, particularly henbane (Hyoscamus niger.)Hyoscyamine is used to provide symptomatic relief to various gastrointestinal disorders including spasms, peptic ulcers, irritable bowel syndrome, pancreatitis, colic and cystitis. It has also been used to relieve some heart problems, control some of the symptoms of Parkinson's disease, as well as for control of respiratory secretions in end of life care [1].
Name (S)-atropine
Synonyms CYSTOSPAZ
L-Hyoscyamine
3a-Tropanyl S-(-)-Tropate
(3-endo)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl-(2S)-3-hydroxy-2-phenylpropanoat
scopolamine HCl
SCOPINE TROPATE
Levsin
(3-endo)-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl (2S)-3-hydroxy-2-phenylpropanoate
(S)-(-)-hyoscyamine
Benzeneacetic acid, α-(hydroxymethyl)-, (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, (αS)-
SCOPINE TROPATE HYDROCHLORIDE
Benzeneacetic acid, α-(hydroxymethyl)-, (3-endo)-8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester, (αS)-
MFCD00067306
(S)-atropine
Hyoscyamine
(-)-Hycosamine
(-)-Hyoscyamine
EINECS 202-933-0
Daturine
chlorhydratedescopolamine
Egacene
1-Tropic Acid Ester with Tropine
(-)-atropine
er),hcl
[3(S)-endo]-a-(Hydroxymethyl)benzeneacetic Acid 8-Methyl-8-azabicyclo[3.2.1]oct-3-yl Ester
Peptard
ScopolamineSeries
L-Tropine tropate
(2S)-(1R,5S)-8-Methyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropanoate
1aH,5aH-Tropan-3a-ol(-)-tropate (Ester)
Description L-Hyoscyamine is a chemical compound, a tropane alkaloid it is the levo-isomer to atropine.Target: mAChRHyoscyamine is a chemical compound, a tropane alkaloid it is the levo-isomer to atropine. It is a secondary metabolite of some plants, particularly henbane (Hyoscamus niger.)Hyoscyamine is used to provide symptomatic relief to various gastrointestinal disorders including spasms, peptic ulcers, irritable bowel syndrome, pancreatitis, colic and cystitis. It has also been used to relieve some heart problems, control some of the symptoms of Parkinson's disease, as well as for control of respiratory secretions in end of life care [1].
Related Catalog
References

[1]. http://www.drugbank.ca/drugs/DB00424
Density 1.2±0.1 g/cm3
Boiling Point 429.8±45.0 °C at 760 mmHg
Melting Point 108.5ºC
Molecular Formula C17H23NO3
Molecular Weight 289.369
Flash Point 213.7±28.7 °C
Exact Mass 289.167786
PSA 49.77000
LogP 1.53
Vapour Pressure 0.0±1.1 mmHg at 25°C
Index of Refraction 1.581
Storage condition 2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NH0875000
CHEMICAL NAME :
Hyoscyamine, (-)-
CAS REGISTRY NUMBER :
101-31-5
LAST UPDATED :
199701
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C17-H23-N-O3
MOLECULAR WEIGHT :
289.41
WISWESSER LINE NOTATION :
T56 A ANTJ A1 GOVYR&1Q -L

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Human - man
DOSE/DURATION :
1471 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970 Volume(issue)/page/year: 2,73,1970
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
95 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 24,138,1965 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - A1029 No. of Facilities: 68 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 2770 (estimated)
Hazard Codes T+: Very toxic;
Risk Phrases R26/28
Safety Phrases 24-45
RIDADR UN 1544 6
WGK Germany 3
RTECS NH0875000
HS Code 2933990090
51-34-3 structure

51-34-3

~%

17659-49-3 structure

17659-49-3
126371-43-5 structure

126371-43-5
101-31-5 structure

101-31-5
Literature: Phytochemistry (Elsevier), , vol. 28, # 12 p. 3507 - 3510
114-49-8 structure

114-49-8

~20%

55869-99-3 structure

55869-99-3
126371-43-5 structure

126371-43-5
101-31-5 structure

101-31-5
Literature: Journal of Natural Products, , vol. 69, # 9 p. 1335 - 1340
16202-15-6 structure

16202-15-6
120-29-6 structure

120-29-6

~%

101-31-5 structure

101-31-5
Literature: Archiv der Pharmazie (Weinheim, Germany), , vol. 240, p. 501
74-88-4 structure

74-88-4

~%

101-31-5 structure

101-31-5
Literature: Journal of the Chemical Society, , vol. 101, p. 950
3144-16-9 structure

3144-16-9
51-55-8 structure

51-55-8

~%

101-31-5 structure

101-31-5
Literature: Journal of the Chemical Society, , vol. 95, p. 1966
51-55-8 structure

51-55-8

~%

13269-35-7 structure

13269-35-7
101-31-5 structure

101-31-5
Literature: Chemistry Letters, , p. 983 - 986
HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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