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143-98-6

143-98-6 structure
143-98-6 structure
  • Name: Dextrorphan tartrate
  • Chemical Name: Dextrorphan tartrate
  • CAS Number: 143-98-6
  • Molecular Formula: C21H29NO7
  • Molecular Weight: 407.457
  • Catalog: analytical chemistry Standard standard material
  • Create Date: 2018-08-19 09:20:16
  • Modify Date: 2024-01-09 18:48:37
  • Dextrophan tartrate is a glutamate receptor antagonist potentially for the treatment of stroke. Dextrorphan (DXO) is a psychoactive drug of the morphinan chemical class which acts as an antitussive or cough suppressant and dissociative hallucinogen. It is the dextrorotatory-stereoisomer of racemorphan, the levo-half being levorphanol. Dextrorphan is produced by O-demethylation of dextromethorphan by CYP2D6. Dextrorphan is an NMDA antagonist and contributes to the psychoactive effects of dextromethorphan.
Name Dextrorphan tartrate
Synonyms (2R,3R)-2,3-Dihydroxysuccinic acid - (9α,13α,14α)-17-methylmorphinan-3-ol (1:1)
Levorphanol tartrate
1,3,4,9,10,10a-Hexahydro-11-methyl-2H-10,4a-iminoethanophenanthren-6-ol tartrate,d
d-1,3,4,9,10,10a-Hexahydro-11-methyl-2H-10,4a-iminoethanophenanthren-6-ol Tartrate
Dextrorphan Tartrate Salt
17-Methyl-morphinan-3-ol,Lg-Hydrogentartrat
d-3-Hydroxy-N-methylmorphinan tartrate
Butanedioic acid, 2,3-dihydroxy-, (2R,3R)-, compd. with (9α,13α,14α)-17-methylmorphinan-3-ol (1:1)
17-methyl-morphinan-3-ol,Lg-hydrogentartrate
MFCD00151495
(+)-(9a,13a,14a)-17-methylmorphinan-3-ol Tartrate (1:1) (Salt)
Dextrophan tartrate
Boiling Point 410.4ºC at 760 mmHg
Melting Point 201-204°C
Molecular Formula C21H29NO7
Molecular Weight 407.457
Flash Point 207.2ºC
Exact Mass 407.194397
PSA 138.53000
LogP 0.89570
Appearance white
Vapour Pressure 2.55E-07mmHg at 25°C
Storage condition −70°C
Water Solubility H2O: >10mg/mL

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QD1930000
CAS REGISTRY NUMBER :
143-98-6
LAST UPDATED :
199106
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C17-H23-N-O.C4-H6-O6
MOLECULAR WEIGHT :
407.51
WISWESSER LINE NOTATION :
T6 G666/FQ 2AF Q FX ONT&TTJ IQ O &622 QVYQYVQ -D &621

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 109,189,1953
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
800 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 109,189,1953
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
385 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 109,189,1953
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
350 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 109,189,1953
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
42 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
31ZPAG "Synthetic Analgesics," Oxford, Pergamon Press, 1966 Volume(issue)/page/year: 2,77,1966
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
17414 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 145,11,1964
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
27500 ug/kg
TOXIC EFFECTS :
Behavioral - muscle weakness Behavioral - rigidity (including catalepsy) Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 109,189,1953
Symbol GHS02 GHS06 GHS08
GHS02, GHS06, GHS08
Signal Word Danger
Hazard Statements H225-H301 + H311 + H331-H370
Precautionary Statements P210-P260-P280-P301 + P310-P311
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn
Risk Phrases R22
Safety Phrases 7-16-36/37-45
RIDADR UN1230 - class 3 - PG 2 - Methanol, solution
RTECS QD1930000
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