131179-95-8
131179-95-8 structure
- Name: Efaproxiral
- Chemical Name: 2-[4-[2-(3,5-dimethylanilino)-2-oxoethyl]phenoxy]-2-methylpropanoic acid
- CAS Number: 131179-95-8
- Molecular Formula: C20H23NO4
- Molecular Weight: 341.40100
- Catalog: Research Areas Cancer
- Create Date: 2018-03-05 08:00:00
- Modify Date: 2024-01-09 23:06:43
-
Efaproxiral is a synthetic allosteric modifier of haemoglobin (Hb), decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy.in vitro: Efaproxiral increases oxygen levels in hypoxic tumor tissues by binding non-covalently to the hemoglobin tetramer and decreasing hemoglobin-oxygen binding affinity. Increasing tumor oxygenation reduces tumor radioresistance. Efaproxiral can enhance the oxygenation of hypoxic tumours and function as a radiation sensitiser, increasing the effectiveness of RT.
| Name | 2-[4-[2-(3,5-dimethylanilino)-2-oxoethyl]phenoxy]-2-methylpropanoic acid |
|---|---|
| Synonyms |
2-Dacmpp
Efaproxyn 2-[4-((((3,5-dimethylphenyl)-amino)carbonyl)methyl)phenoxy]-2-methyl propionic acid RSR13 2-(4-(((3,5-dimethylanilino)carbonyl)methyl)phenoxy)-2-methylpropionic acid Efaproxiral 2-(4-(2-((3,5-Dimethylphenyl)amino)-2-oxoethyl)phenoxy)-2-methylpropanoic acid Efaproxiral Sodium |
| Description | Efaproxiral is a synthetic allosteric modifier of haemoglobin (Hb), decreases Hb-oxygen (O2) binding affinity and enhances oxygenation of hypoxic tumours during radiation therapy.in vitro: Efaproxiral increases oxygen levels in hypoxic tumor tissues by binding non-covalently to the hemoglobin tetramer and decreasing hemoglobin-oxygen binding affinity. Increasing tumor oxygenation reduces tumor radioresistance. Efaproxiral can enhance the oxygenation of hypoxic tumours and function as a radiation sensitiser, increasing the effectiveness of RT. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.202g/cm3 |
|---|---|
| Boiling Point | 554.5ºC at 760mmHg |
| Molecular Formula | C20H23NO4 |
| Molecular Weight | 341.40100 |
| Flash Point | 289.2ºC |
| Exact Mass | 341.16300 |
| PSA | 75.63000 |
| LogP | 3.79960 |
| Vapour Pressure | 3.93E-13mmHg at 25°C |
| Index of Refraction | 1.597 |
| Storage condition | 2-8℃ |
| HS Code | 2924299090 |
|---|
|
~89%
131179-95-8 |
| Literature: Chemical Communications, , # 9 p. 1100 - 1102 |
|
~82%
131179-95-8 |
| Literature: Synthetic Communications, , vol. 36, # 15 p. 2129 - 2133 |
|
~68%
131179-95-8 |
| Literature: Journal of Medicinal Chemistry, , vol. 34, # 2 p. 752 - 757 |
|
~%
131179-95-8 |
| Literature: Synthetic Communications, , vol. 36, # 15 p. 2129 - 2133 |
|
~%
131179-95-8 |
| Literature: Synthetic Communications, , vol. 36, # 15 p. 2129 - 2133 |
|
~%
131179-95-8 |
| Literature: Journal of Mass Spectrometry, , vol. 41, # 3 p. 332 - 338 |
| Precursor 7 | |
|---|---|
| DownStream 0 | |
| HS Code | 2924299090 |
|---|---|
| Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |