14860-49-2
14860-49-2 structure
- Name: Clobutinol
- Chemical Name: 1-(4-chlorophenyl)-4-(dimethylamino)-2,3-dimethylbutan-2-ol
- CAS Number: 14860-49-2
- Molecular Formula: C14H22ClNO
- Molecular Weight: 255.78400
- Catalog: API Respiratory medication Antitussive
- Create Date: 2018-03-14 08:00:00
- Modify Date: 2026-07-01 11:30:30
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Clobutinol is a compound that has anti-tussive effects. Clobutinol affects heart rate and blood pressure, it can be used for cough related research[1][2][3].
| Name | 1-(4-chlorophenyl)-4-(dimethylamino)-2,3-dimethylbutan-2-ol |
|---|---|
| Synonyms |
4-Chloro-α-[2-(dimethylamino)-1-methylethyl]-α-methylphenethyl alcohol
4-Chloro-α-methyl-α-[2-(dimethylamino)-1-methylethyl]phenethyl alcohol 1-(p-Chlorophenyl)-4-(dimethylamino)-2,3-dimethyl-2-butanol Benzeneethanol, 4-chloro-α-[2-(dimethylamino)-1-methylethyl]-α-methyl Clobutinol HCl Clobutinol (base and/or unspecified salts) Clobutinol //BP 2-(p-Chlorobenzyl)-3-dimethylaminomethyl-2-butano 1-(4-chlorophenyl)-4-(dimethylamino)-2,3-dimethyl-butan-2-ol EINECS 238-926-4 1-p-Chlorophenyl-2,3-dimethyl-4-dimethylamino-2-butanol |
| Description | Clobutinol is a compound that has anti-tussive effects. Clobutinol affects heart rate and blood pressure, it can be used for cough related research[1][2][3]. |
|---|---|
| Related Catalog | |
| In Vitro | Clobutinol (10 μM) significantly inhibits the voltage-gated outward current in hERG-expressing cells[1]. Clobutinol (0-1000 μM) inhibits the outward current in hERG transfected cells with an IC50 value of 1.9 μM[1]. |
| In Vivo | Clobutinol (1-20 mg/kg; i.v. once) has no obvious effect on the airway of guinea-pigs[2]. Clobutinol (1 and 10 mg/kg; i.v. once) affects heart rate and mean blood pressure of guinea pigs[3]. Animal Model: Anaesthetized guinea-pigs[2] Dosage: 1-20 mg/kg Administration: Intravenous injection; 1-20 mg/kg once Result: Showed no obvious effect on the airways, but affected the cardiovascular system considerably with a high dose. Animal Model: Anesthetized closed-chest guinea pigs[3] Dosage: 1 and 10 mg/kg Administration: Intravenous injection; 1 and 10 mg/kg once Result: Decreased the heart rate with a dose of 1 mg/kg, and decreased the heart rate and mean blood pressure with a dose of 10 mg/kg. |
| References |
| Density | 1.0373 (rough estimate) |
|---|---|
| Boiling Point | bp12 179-180° |
| Molecular Formula | C14H22ClNO |
| Molecular Weight | 255.78400 |
| Exact Mass | 255.13900 |
| PSA | 23.47000 |
| LogP | 2.83120 |
| Index of Refraction | 1.6330 (estimate) |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| HS Code | 2922199090 |
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| HS Code | 2922199090 |
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| Summary | 2922199090. other amino-alcohols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |