828271-96-1

828271-96-1 structure

Name: Valategrast hydrochloride
Chemical Name: 2-(Diethylamino)ethyl N-(2-chloro-6-methylbenzoyl)-4-[(2,6-dichlo robenzoyl)amino]-L-phenylalaninate hydrochloride (1:1)
CAS Number: 828271-96-1
Molecular Formula: C₃₀H₃₃Cl₄N₃O₄
Molecular Weight: 641.41300
Catalog: Signaling Pathways Cytoskeleton Integrin
Create Date: 2017-09-05 09:20:32
Modify Date: 2024-01-12 16:15:49
Valategrast hydrochloride (R-411) is a potent integrin α4β1 (VLA-4) and α4β7 dual antagonist. Valategrast hydrochloride has the potential for Chronic obstructive pulmonary disease (COPD) and asthma treatment[1][2].

Name	2-(Diethylamino)ethyl N-(2-chloro-6-methylbenzoyl)-4-[(2,6-dichlo robenzoyl)amino]-L-phenylalaninate hydrochloride (1:1)

Description	Valategrast hydrochloride (R-411) is a potent integrin α4β1 (VLA-4) and α4β7 dual antagonist. Valategrast hydrochloride has the potential for Chronic obstructive pulmonary disease (COPD) and asthma treatment[1][2].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Cytoskeleton >> Integrin
Target	α4β1 α4β7
In Vitro	Valategrast (hydrochloride) contains a common l-phenylalanine-N-aroyl motif where the carboxylic acid is responsible for binding to the metal ion in the metal-ion-dependent adhesion site (MIDAS)[2].
References	[1]. Woodside DG, et al. Cell adhesion antagonists: therapeutic potential in asthma and chronic obstructive pulmonary disease. BioDrugs. 2008;22(2):85-100. [2]. Halland N, et al. Small Macrocycles As Highly Active Integrin α2β1 Antagonists. ACS Med Chem Lett. 2014 Jan 10;5(2):193-8.