910484-28-5

910484-28-5 structure

Name: TTA-Q6
Chemical Name: 4-[(4S)-6-Chloro-4-cyclopropyl-2-oxo-3-(2,2,2-trifluoroethyl)-1,2 ,3,4-tetrahydro-4-quinazolinyl]benzonitrile
CAS Number: 910484-28-5
Molecular Formula: C₂₀H₁₅ClF₃N₃O
Molecular Weight: 405.80100
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Calcium Channel
Create Date: 2016-01-15 02:23:21
Modify Date: 2024-01-10 11:26:25
TTA-Q6 is a selective T-type Ca2+ channel antagonist, used in the neurological disease.

Name	4-[(4S)-6-Chloro-4-cyclopropyl-2-oxo-3-(2,2,2-trifluoroethyl)-1,2 ,3,4-tetrahydro-4-quinazolinyl]benzonitrile
Synonyms	DETROL tolterodine tartarate TOLERODINETARTRATE Detrol LA TOLTERODINE L-TARTRATE DETRUSITOL Tolterodine Tartrate API TTA-Q6

Description	TTA-Q6 is a selective T-type Ca2+ channel antagonist, used in the neurological disease.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Neurological Disease
Target	T-type Ca2+ channel[1]
In Vitro	TTA-Q6 is a selective T-type Ca2+ channel antagonist, with 14 nM and 590 nM in FLIPR depolarized assaay and FLIPR hyperpolarized assay[1].
References	[1]. Schlegel KA, et al. Discovery and expanded SAR of 4,4-disubstituted quinazolin-2-ones as potent T-type calcium channel antagonists. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5147-52.